Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome

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dc.contributor.authorAslan, Eyup
dc.contributor.authorSert, Ahmet
dc.contributor.authorBuyukinan, Muammer
dc.contributor.authorPirgon, Mustafa Ozgur
dc.contributor.authorKurku, Huseyin
dc.contributor.authorYilmaz, Hakan
dc.contributor.authorOdabas, Dursun
dc.date.accessioned2024-02-23T14:16:33Z
dc.date.available2024-02-23T14:16:33Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractPurpose: The aim of our study was to assess left ventricle and right ventricle systolic and diastolic functions in obese adolescents with metabolic syndrome using conventional echocardiography and pulsed-wave tissue Doppler imaging and to investigate carotis intima-media thickness, and asymmetric dimethyl arginine levels. Methods: A total of 198 obese adolescents were enrolled in the study. The obese patients were divided into metabolic syndrome group and non-metabolic syndrome group. All subjects underwent laboratory blood tests, including asymmetric dimethyl arginine, complete two-dimensional, pulsed, and tissue Doppler echocardiography, and measurement of the carotid intima-media thickness. Results: Obese adolescents were characterised by enlarged left end-diastolic, end-systolic and left atrial diameters, thicker left and right ventricular walls compared with non-obese adolescents. The metabolic syndrome group had normal left ventricle systolic function, impaired diastolic function, and altered global systolic and diastolic myocardial performance. In the metabolic syndrome obese group patients, left ventricle mass was found positively correlated with body mass index, waist and hip circumferences, diastolic blood pressure, age, and waist-to-hip circumference ratio. The carotid intima-media thickness was found positively correlated with waist and hip circumferences and total cholesterol levels. Asymmetric dimethyl arginine levels were found positively correlated with systolic blood pressure, waist-to-hip circumference ratio, and diastolic blood pressure. Conclusions: The results of this study demonstrate that metabolic syndrome in adolescence is associated with significant changes in myocardial geometry and function. In addition, it has been associated with a high level of asymmetric dimethyl arginine concentration and thicker carotid intima-media thickness reflecting endothelial dysfunction.en_US
dc.identifier.doi10.1017/S1047951118002329
dc.identifier.endpage318en_US
dc.identifier.issn1047-9511
dc.identifier.issn1467-1107
dc.identifier.issue3en_US
dc.identifier.pmid30688191en_US
dc.identifier.scopus2-s2.0-85060778889en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage310en_US
dc.identifier.urihttps://doi.org/10.1017/S1047951118002329
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12713
dc.identifier.volume29en_US
dc.identifier.wosWOS:000463109300010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofCardiology In The Youngen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdolescenten_US
dc.subjectAsymmetric Dimethyl Arginineen_US
dc.subjectCardiovascular Diseaseen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectMetabolic Syndromeen_US
dc.titleLeft and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndromeen_US
dc.typeArticleen_US

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