Pretreatment with carnosol in lung ischemia reperfusion-induced renal injury

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dc.contributor.authorApiliogullari, Burhan
dc.contributor.authorKesli, Recep
dc.contributor.authorEsme, Hidir
dc.contributor.authorYuceaktas, Ali
dc.contributor.authorYoldas, Banu
dc.date.accessioned2024-02-23T14:44:41Z
dc.date.available2024-02-23T14:44:41Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBackground: This experimental study aims to investigate the protective effects of carnosol on kidney injury induced by lung ischemia/reperfusion (I/R). Methods: Twenty-four New Zealand white rabbits were randomized into three groups. Group IR; lung I/R group (60 min ischemia-60 min reperfusion), group CIR; bolus injection of carnosol before lung I/R, and group S; sham group (pulmonary hilum was not clamped). Renal tissue myeloperoxidase (MPO) and intercellular adhesion molecule-1 (ICAM-1) levels were evaluated. Results: Renal tissue MPO and ICAM-1 levels were significantly higher in the group IR compared to the group CIR and group S (p=0.021 and p=0.0001 respectively). No statistically significant difference in the parameters evaluated was detected between the group CIR and the group S. Conclusion: Our study result suggests that lung I/R injury causes increased renal tissue MPO and ICAM-1 levels, which are related to activated neutrophil sequestration and carnosol may play a protective role against this kidney injury.en_US
dc.description.sponsorshipKonya Education and Research Hospital's Research Projects Funden_US
dc.description.sponsorshipThis work was supported by Konya Education and Research Hospital's Research Projects Fund.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2014.9362
dc.identifier.endpage820en_US
dc.identifier.issn1301-5680
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84908567797en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage816en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2014.9362
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17052
dc.identifier.volume22en_US
dc.identifier.wosWOS:000344308800017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal Of Thoracic And Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarnosolen_US
dc.subjectIschemia Reperfusionen_US
dc.subjectLungen_US
dc.subjectRenal Injuryen_US
dc.titlePretreatment with carnosol in lung ischemia reperfusion-induced renal injuryen_US
dc.typeArticleen_US

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