Comparison of the Depth of Anesthesia Produced with Dexmedetomidine-Sevoflurane or Medetomidine-Sevoflurane by Using Bispectral Index Monitoring

Basit Öğe Kaydı
dc.contributor.authorSaritas, Zulfikar Kadir
dc.contributor.authorKorkmaz, Musa
dc.contributor.authorSaritas, Tuba Berra
dc.contributor.authorSivaci, Remziye Gul
dc.date.accessioned2024-02-23T14:45:54Z
dc.date.available2024-02-23T14:45:54Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBackground: Bispectral index (BIS) monitor was developed to utilize the depth of anesthesia by estimating electroencephalogram (EEG) signals. BIS, which is the numerical value of EEG derivative, is used for evaluation of depression of central nervous system (CNS) in human medicine. The depressive effect of sedative and anaesthetic agents on CNS in human is correlated to BIS. Dexmedetomidine (DEX) is administered as continuous infusion during anesthesia and surgery in humans. DEX is a hypnotic with high selectivity for alpha 2-adrenergic receptors. Materials, Methods & Results: Adult female New Zealand rabbits (mean +/- SD body weight 3.8 +/- 0.5 kg) were procured from a certified commercial source to use in medical researches. The animal number in each of the two study groups was four, for a total of eight. The rabbits were randomly divided into two equal groups (n = 4). The rabbits DEX group were administered 20 mcg/kg of i.v. DEX HCI for premedication. Medetomidine (MED) group was administered 20 mcg/kg of iv MED for premedication. Induction was provided by 5% of sevoflurane + 4 L/min oxygen via glove mask in the both groups. General anesthesia was maintained with 3% of sevoflurane + oxygen on spontaneous respiration for 30 min. The animals' temporomandibular region was shaved; its fat was eliminated with ether before the study. Human sensors were used as BIS sensor consisted of 5 electrodes. Three were placed into frontal area as the remaining two into the pre-auricular area. After ensuring the connection of the sensor to the BIS monitor, BIS value was continuously followed and recorded at 0 min (T0), 1st (T1), 5th (T5), 7th (T7), 9th (T9), 15th (T15) 20th (T20), 25th (T25) and at 30th min (T30) in both groups while the rabbits were awake. At T1 measure point, DEX and MED were applied; sedation was produced at T5; 5% of sevoflurane was administered through glove-mask method at T7 for induction; general anesthesia was obtained at T9 and continued during T15, T20, T25 and T30; they were awakened at the end of 30th min. On the day preceding the study, they were sedated; their femoral arteries were localized and catheterized under local anesthesia following sedation. At T0, T1, T5, T7, T9, T15, T20, T25 and T30 measure time points, the catheter-transducer connection was established for mean arterial blood pressure (MAP) measurement; for ECG monitoring, ECG electrodes were attached to all four extremities of the subjects and, ECG tracings from lead II were monitored and recorded on the multi-channel monitor. The pH was kept between 7.35 - 7.45, as PCO2 between 35 - 45 mmHg. All animals in both groups were documented during the study for Anesthesia Score (AS). MAP and BIS decline in DEX group at the end of 1st min at statistical significance (P < 0.05). At the same time point, AS was recorded higher in DEX group (P < 0.05). In the comparison of DEX group with MED group at T5; HR, MAP and BIS markedly declined in DEX group (P < 0.05); however, AS was found higher in DEX group as being statistically significant at the same time point (P < 0.05). As it was at T5, Heart Rate (HR), MAP and BIS were also found statistically significantly low in DEX group at T7 and T9; while AS was found higher as compared to MED group (P < 0.05). BIS value in MED group was low at a statistical significance level at T15, T20, T25 and T30 time points (P < 0.05). Discussion: In present study, sevoflurane administration with glove mask method provides sufficient anesthesia in the rabbits which were premedicated with DEX and MED in experimental studies or surgical procedures during veterinary practice. Besides the vital parameters and AS monitoring, BIS monitoring is also an effective method in determination of the depth of anesthesia in rabbits.en_US
dc.identifier.issn1678-0345
dc.identifier.issn1679-9216
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17676
dc.identifier.volume42en_US
dc.identifier.wosWOS:000339159700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherUniv Fed Rio Grande Do Sulen_US
dc.relation.ispartofActa Scientiae Veterinariaeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBispectral Indexen_US
dc.subjectRabbitsen_US
dc.subjectDexmedetomidineen_US
dc.subjectMedetomidineen_US
dc.subjectSevofluraneen_US
dc.subjectHemodynamic Parametersen_US
dc.titleComparison of the Depth of Anesthesia Produced with Dexmedetomidine-Sevoflurane or Medetomidine-Sevoflurane by Using Bispectral Index Monitoringen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu