How does neurokinin 3 receptor agonism affect pathological and cognitive impairments in an Alzheimer's disease-like rat model?

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dc.authoridRaviye Özen Koca: 0000-0001-6295-5548en_US
dc.authoridZülfikare Işık Solak Görmüş: 0000-0001-6762-6225en_US
dc.authoridHatice Solak: 0000-0002-3554-3051en_US
dc.authoridAynur Koç: 0000-0001-5532-3737en_US
dc.authoridİbrahim Kılınç: 0000-0002-7729-7557en_US
dc.authoridMehmet Sinan İyisoy: 0000-0001-5895-9984en_US
dc.authoridSelim Kutlu: 0000-0001-9257-4797en_US
dc.contributor.authorÖzen Koca, Raviye
dc.contributor.authorSolak Görmüş, Zülfikare Işık
dc.contributor.authorSolak, Hatice
dc.contributor.authorKoç, Aynur
dc.contributor.authorKılınç, İbrahim
dc.contributor.authorİyisoy, Mehmet Sinan
dc.contributor.authorKutlu, Selim
dc.date.accessioned2023-04-07T10:53:27Z
dc.date.available2023-04-07T10:53:27Z
dc.date.issued2023en_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıp Eğitimi ve Bilişimi Anabilim Dalıen_US
dc.descriptionMakale (Early Access)en_US
dc.descriptionWOS:000926317400001en_US
dc.descriptionPubMed ID:36745246en_US
dc.description.abstractAlzheimer's disease (AD) is accepted as a form of progressive dementia. Cholinergic systems are commonly affected in AD. Neurokinin 3 receptor (NK3R) is involved in learning memory-related processes. It is known that the activation of NK3R affects the release of many neurotransmitters. The aim of this project was to investigate the effects of NK3R agonist senktide administration on neurobehavioral mechanisms in the experimental AD-like rat model. 50 male Wistar albino rats were divided into Control (C), AD, Control + NK3R agonist (CS), AD + NK3R agonist (ADS), AD + NK3Ragonist + antagonist groups (ADSO). We designed AD-like model by intrahippocampal administration of A beta 1-42. After NK3R agonist + antagonist injections, open field (OF), Morris water maze (MWM) tests were applied. Cholinergic mechanism analysis from hippocampus-cortex tissues was performed by ELISA and catecholamine analysis from brain stem tissue were performed by HPLC method. The transitions from edge to center, rearing, grooming parameters were found to be reduced in final values of OF. While the group-time interaction was significant in the OF test findings, there was no significant difference between the groups. In MWM test, ADS group showed a learning level close to control group and animals in AD and ADSO groups could not learn target quadrant in MWM test. The brain stem NA and DA concentrations were not statistically significant. Hippocampal AChE-ChAT levels were supported by positive effects of senktide on learning via the cholinergic mechanisms. As a result, NK3R agonists were found to be effective in improving cognitive functions in rats with AD pathology. In the experimental AD model, positive effects of NK3R on learning memory may be mediated by cholinergic mechanisms.en_US
dc.description.sponsorshipScientific Research Projects (BAP) Coordination Unit of Necmettin Erbakan Universityen_US
dc.identifier.citationÖzen Koca, R., Solak Görmüş, Z. I., Solak, H., Koç, A., Kılınç, İ., İyisoy, M. S., Kutlu, S. (2023). How does neurokinin 3 receptor agonism affect pathological and cognitive impairments in an Alzheimer's disease-like rat model. Amino Acids, 1-18.en_US
dc.identifier.doi10.1007/s00726-023-03241-0en_US
dc.identifier.endpage18en_US
dc.identifier.issn0939-4451en_US
dc.identifier.issn1438-2199en_US
dc.identifier.issue-en_US
dc.identifier.pmid36745246en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s00726-023-03241-0
dc.identifier.urihttps://hdl.handle.net/20.500.12452/9391
dc.identifier.volume-en_US
dc.identifier.wosWOS:000926317400001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofAmino Acidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAlzheimer’s Diseaseen_US
dc.subjectNeurokinin 3 Receptoren_US
dc.subjectLearning and Memoryen_US
dc.subjectCholinergic Mechanismen_US
dc.subjectCatecholaminergic Mechanismen_US
dc.titleHow does neurokinin 3 receptor agonism affect pathological and cognitive impairments in an Alzheimer's disease-like rat model?en_US
dc.typeArticleen_US

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