Antioxidant effects of ankaferd blood stopper doped polyvinyl pyrolidon in an experimental model created in insect

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dc.contributor.authorGunes, Eda
dc.date.accessioned2024-02-23T14:02:56Z
dc.date.available2024-02-23T14:02:56Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractThis research evaluated Ankaferd Blood Stopper (ABS)-doped Polyvinylpyrrolidone (PVP) nanofiber layers which were produced with the electrospinning method for their potential for co-use in response to oxidative stress. As a result of the use of such a preparation (ABS doped PVP) in long-term treatments, the response to oxidative stress was compared to biochemical parameters, and its effect on sex was also aimed to be determined. For this purpose, Drosophila melanogaster foods were coated with 10% PVP, ABS (2 ml) and PVP-ABS. In total, 300 flies were randomized into 6 groups, each consisting of 25 female and 25 male insects, and the insects were fed with the determined coated mediums. The effects of foods on adult flies were tested for biochemical changes (Malon-dialdehyde-MDA and Total oxidation status-TOS, Glutathione-S-Transferase-GST, Catalase-CAT and Superoxide dismutase-SOD activities, Total antioxidant capacity-TAS) at the end of ten days. It was determined that the separate use of the two substances increased the amount of MDA in both sexes. It was found that the combined use of PVP-ABS had a positive effect similar to the control by increasing the antioxidant enzymes (SOD, CAT, GST). Feeding with ABS-doped PVP in the male insects reduced TOS (2.00 +/- 0.01 mu mol H(2)O(2)Eq/L), but the female insects were found to have higher OSI (40.00 +/- 0.01 mu mol H(2)O(2)Eq/L). As a result, PVP-ABS may be used together as an antioxidant, but more detailed studies are needed for their safe use on both sexes.en_US
dc.identifier.doi10.1016/j.fct.2020.111935
dc.identifier.issn0278-6915
dc.identifier.issn1873-6351
dc.identifier.pmid33348050en_US
dc.identifier.scopus2-s2.0-85098140504en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.fct.2020.111935
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11904
dc.identifier.volume148en_US
dc.identifier.wosWOS:000610832800010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofFood And Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDrosophilaen_US
dc.subjectElectrospinningen_US
dc.subjectNanofiberen_US
dc.subjectTotal Oxidation Statusen_US
dc.subjectGenderen_US
dc.subjectAgingen_US
dc.titleAntioxidant effects of ankaferd blood stopper doped polyvinyl pyrolidon in an experimental model created in insecten_US
dc.typeArticleen_US

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