An update on diagnosis and treatment of ANCA associated renal vasculitis

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dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorOzer, Hakan
dc.contributor.authorTesar, Vladimir
dc.date.accessioned2024-02-23T13:59:29Z
dc.date.available2024-02-23T13:59:29Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractAnti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a group of diseases characterised by necrotizing inflammation of small vessels such as arterioles, venules, and capillaries. ANCA-associated vasculitides (AAV) are referred to as small vessel vasculitides. Three AAV subgroups, namely granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic GPA (EGPA), are defined according to clinical features. The most common disease with renal involvement in AAV is MPA Approximately 90% of patients with MPA have renal involvement. While this rate is 70-80% in GPA, less than half of EGPA patients have renal involvement. Untreated survival in AAVs is less than one year. With appropriate immunosuppressive therapy, the 5-year renal survival rate is 70-75%. Without therapy, the prognosis is poor but treatments, typically immunosuppressants, have improved survival, albeit with considerable morbidity from glucocorticoids and other immunosuppressive medications. Current challenges include improving the measures of disease activity and risk of relapse, uncertainty about optimal therapy duration and a need for targeted therapies with fewer adverse effects. In this review, we described the treatment of renal involvement in AAV in line with current studies.en_US
dc.identifier.doi10.1007/s11255-023-03565-6
dc.identifier.endpage2827en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue11en_US
dc.identifier.pmid37010734en_US
dc.identifier.scopus2-s2.0-85151436464en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2817en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-023-03565-6
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11213
dc.identifier.volume55en_US
dc.identifier.wosWOS:000962698100001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology And Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Neutrophil Cytoplasmic Antibodyen_US
dc.subjectGranulomatosis With Polyangiitisen_US
dc.subjectMicroscopic Polyangiitisen_US
dc.subjectEosinophilic Gpaen_US
dc.titleAn update on diagnosis and treatment of ANCA associated renal vasculitisen_US
dc.typeReview Articleen_US

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