Effect of Human Papillomavirus Subtype on the Rate of Positive Surgical Margin After Cervical Conization

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dc.contributor.authorPurut, Yunus Emre
dc.contributor.authorGiray, Burak
dc.contributor.authorAkis, Serkan
dc.contributor.authorPeker, Esra Keles
dc.contributor.authorBabayeva, Gulchin
dc.contributor.authorKabaca, Canan
dc.contributor.authorApi, Murat
dc.date.accessioned2024-02-23T14:27:00Z
dc.date.available2024-02-23T14:27:00Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjective. Human papillomavirus (HPV) infection is a risk factor for cervical carcinoma. Over 100 types of HPV have been identified. The excisional procedures are recommended for women with high-grade cervical intraepithelial neoplasia. Surgical margin status is an important predictor of the risk of relapse. The aim of the current study was to evaluate whether HPV genotype is a predictive factor of positive surgical margin after cervical cone excision. Materials and Methods. The records of 448 HPV-infected patients who underwent loop electrosurgical excision or cold knife conization at a tertiary gynecological cancer center were retrospectively reviewed. The patients were divided into 6 groups according to HPV positivity: HPV 16 only, HPV 18 only, HPV 16/18, other high-risk HPV (hrHPV), HPV 16/hrHPV, and HPV 18/hrHPV. Results. There was no significant difference between the HPV groups in terms of age, parity, menopausal status, endocervical canal involvement, conization method, and the rates of positive margin (P = .15, P = .49, P = .07, P = .20, P = .24, P = .39, respectively). Conclusion. The results show that HPV subtypes might not be associated with endocervical canal involvement and the rates of positive margin. In addition, margin status was not related to the conization method and the number of excised cervical tissue.en_US
dc.identifier.doi10.1177/10668969221143460
dc.identifier.endpage25en_US
dc.identifier.issn1066-8969
dc.identifier.issn1940-2465
dc.identifier.issue1en_US
dc.identifier.pmid36514291en_US
dc.identifier.scopus2-s2.0-85144181499en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org/10.1177/10668969221143460
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14412
dc.identifier.volume31en_US
dc.identifier.wosWOS:000898297500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofInternational Journal Of Surgical Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCervical Intraepithelial Neoplasiaen_US
dc.subjectConizationen_US
dc.subjectHuman Papillomavirusen_US
dc.subjectLoop Electrosurgical Excisionen_US
dc.titleEffect of Human Papillomavirus Subtype on the Rate of Positive Surgical Margin After Cervical Conizationen_US
dc.typeArticleen_US

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