Evaluation of the relationship between fungal infection, neutrophil leukocytes and macrophages in cervicovaginal smears: Light microscopic examination

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dc.contributor.authorDemirezen, Sayeste
dc.contributor.authorDonmez, Hanife Guler
dc.contributor.authorOzcan, Merve
dc.contributor.authorBeksac, Mehmet Sinan
dc.date.accessioned2024-02-23T14:37:43Z
dc.date.available2024-02-23T14:37:43Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground: Right after opportunistic fungi become pathogenic, they face immune system cells including macrophages and neutrophil leukocytes. Although the relationship between fungi and immune cells are being widely studied by using animal models and culture techniques, cervicovaginal smears have not been used to evaluate this interaction yet. Aim: The aim of this study was to investigate the interactions between fungal infection, macrophages and neutrophil leukocytes in cervicovaginal smear. Materials and Methods: Papanicolaou-stained cervicovaginal smears from 2307 women, aged between 18 and 73 years, were examined by light microscopy. Periodic acid-Schiff stain was also used to confirm the presence of fungal cell walls. Results: Fungal infections were detected in 239 of 2307 patients (10.4%), and these cases were taken as the study group. Cases without any infectious agents (n = 1800, 78%) were considered as the control group. When the study and control groups were statistically compared in view of macrophages and neutrophil leukocytes, a significant relationship between presence of fungal infection, macrophages and neutrophil leukocytes was detected (P < 0.05). Furthermore, macrophages and neutrophil leukocytes were found to work against the fungal infection together (P < 0.05). Additionally, when the relationship between the existence of yeast or filamentous forms and these immune cells were evaluated, a significant correlation was not found (P > 0.05). Conclusions: Our findings indicate that macrophages and neutrophils may play a determining role in host defense against fungal infection together, but neither yeast nor filamentous forms affect the presence of neutrophil leukocytes and macrophages. As a result of this, both yeast and filamentous forms may have pathogenic effects.en_US
dc.identifier.doi10.4103/0970-9371.160544
dc.identifier.endpage84en_US
dc.identifier.issn0970-9371
dc.identifier.issn0974-5165
dc.identifier.issue2en_US
dc.identifier.pmid26229242en_US
dc.identifier.scopus2-s2.0-84937934470en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.4103/0970-9371.160544
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16215
dc.identifier.volume32en_US
dc.identifier.wosWOS:000358433200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal Of Cytologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCandidaen_US
dc.subjectCervicovaginal Smearen_US
dc.subjectFungal Infectionen_US
dc.subjectInnate Immune Systemen_US
dc.subjectMacrophageen_US
dc.subjectNeutrophilen_US
dc.titleEvaluation of the relationship between fungal infection, neutrophil leukocytes and macrophages in cervicovaginal smears: Light microscopic examinationen_US
dc.typeArticleen_US

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