Daptomycin versus Vancomycin in an Enterococcus faecalis Endophthalmitis Rabbit Model

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dc.contributor.authorOzcimen, Muammer
dc.contributor.authorKurtoglu, Muhammet G.
dc.contributor.authorGoktas, Sertan
dc.contributor.authorOmeroglu, Ethem
dc.contributor.authorSakarya, Yasar
dc.contributor.authorAlpfidan, Ismail
dc.contributor.authorOzcimen, Serap
dc.date.accessioned2024-02-23T14:34:36Z
dc.date.available2024-02-23T14:34:36Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractPurpose: To compare bactericidal activities of daptomycin (DAP) and vancomycin (VAN) in an experimental rabbit model of Enterococcus faecalis endophthalmitis. Materials and methods: The right vitreous cavities of 24 New Zealand rabbits were inoculated with 100 colony-forming units of E. faecalis; and after 24 h, rabbits were randomly divided into three groups. DAP group (n = 8, 0.2 mg/0.05 ml intravitreally), VAN group (n = 8, 1 mg/0.05 ml intravitreally) and balanced salt solution group (BSS, n = 8, 0.05 ml intravitreally). Clinical examination scores were recorded, and vitreous aspirates were obtained for microbiological analysis on days 0, 1, 2, 3 and 4. Rabbits were sacrificed, and the eyes were enucleated for histopathological assessment. Results: There was no difference between the DAP, VAN and BSS groups in terms of the clinical grading of endophthalmitis 24 h after the inoculation. The bacterial counts were similar between the VAN and DAP groups except on day 1, where it was significantly lower than those in the VAN group (p = 0.003). On day 4, 62% of the eyes treated with DAP, and 50% of the eyes treated with VAN were sterilized. All of the eyes from the BSS group showed increasing bacterial growth from day 0 to day 4. There was no difference between the DAP and VAN groups in terms of the histopathological and clinical examination scores, while they were significantly lower than those in the BSS group. Conclusions: This study demonstrates evidence of the effectiveness of DAP for the treatment of experimental E. faecalis endophthalmitis.en_US
dc.description.sponsorshipKonya Training and Research Hospital, Konya, Turkey [KTRH-28]en_US
dc.description.sponsorshipThis work was supported by grants from Konya Training and Research Hospital (KTRH-28), Konya, Turkey.en_US
dc.identifier.doi10.3109/02713683.2015.1004722
dc.identifier.endpage239en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue2en_US
dc.identifier.pmid25658242en_US
dc.identifier.scopus2-s2.0-84957433231en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage232en_US
dc.identifier.urihttps://doi.org/10.3109/02713683.2015.1004722
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15654
dc.identifier.volume41en_US
dc.identifier.wosWOS:000375398200012en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDaptomycinen_US
dc.subjectEndophthalmitisen_US
dc.subjectEnterococcus Faecalisen_US
dc.subjectRabbiten_US
dc.subjectVancomycinen_US
dc.titleDaptomycin versus Vancomycin in an Enterococcus faecalis Endophthalmitis Rabbit Modelen_US
dc.typeArticleen_US

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