The relationship between lichen planus and metabolic syndrome

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dc.contributor.authorDaye, Munise
dc.contributor.authorTemiz, Selami Aykut
dc.contributor.authorIsik, Begum
dc.date.accessioned2024-02-23T14:24:29Z
dc.date.available2024-02-23T14:24:29Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective Lichen planus (LP) is an idiopathic, chronic inflammatory disease. Chronic inflammatory diseases can cause metabolic complications. In the literature, data related to the relationship between lichen planus and metabolic syndrome (MS) are limited. We aimed to evaluate the relationship between MS and lichen planus with disease activity. Methods The patients diagnosed with lichen planus at the dermatology outpatient clinic between January 2018 and January 2020 were retrospectively analyzed. 98 lichen planus cases, age- and sex-matched 99 controls, 197 cases in total were included in the study. Results Of the 98 lichen planus cases included in the study, 60 (61%) were women. The mean age of the patients was 49.3 +/- 14.4, and the average disease duration was 33.5 +/- 31.4 months. 55 (55%) of the patients in the control group were female, and the mean age of the control group was 50 +/- 13.2. The body mass index of LP cases was 29.5 +/- 5.8, in the control group was 25.8 +/- 3.7. Metabolic syndrome was found in 47 (48%) of 98 cases with lichen planus and 32.3% in the control group. MS in the lichen planus group was significantly higher than the control group (P = .025). Metabolic syndrome was detected in the oral lichen planus at the rate of 60% (12 cases). Although the incidence of MS was more common in the oral lichen planus, it was not statistically significant (P = .29). While no significant relationship was found between oral disease severity and metabolic syndrome (P = .19), a significant correlation was found between cutaneous disease severity and metabolic syndrome (P = .023). Discussion The risk of mucosal malignancy that can occur when following LP cases has been known for a long time. According to our results, caution should be taken in terms of metabolic complications in the follow-up of LP cases, especially oral LP cases.en_US
dc.identifier.doi10.1111/jocd.13905
dc.identifier.endpage2639en_US
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue8en_US
dc.identifier.pmid33355985en_US
dc.identifier.scopus2-s2.0-85098202228en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2635en_US
dc.identifier.urihttps://doi.org/10.1111/jocd.13905
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13958
dc.identifier.volume20en_US
dc.identifier.wosWOS:000602698500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Cosmetic Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLichen Planusen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectMucosal Involvementen_US
dc.subjectDisease Severityen_US
dc.titleThe relationship between lichen planus and metabolic syndromeen_US
dc.typeArticleen_US

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