Cytokine, chemokine and BDNF levels in medication-free pediatric patients with obsessive-compulsive disorder

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dc.contributor.authorSivri, Rukiye Colak
dc.contributor.authorBilgic, Ayhan
dc.contributor.authorKilinc, Ibrahim
dc.date.accessioned2024-02-23T13:55:54Z
dc.date.available2024-02-23T13:55:54Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractThe aim of this study was to investigate whether the serum levels of IL-12, IL-17, TGF beta, TNF-alpha, sTNFR1, sTNFR2, IL-1 beta, CCL3, CCL24, CXCL8, and BDNF are associated with obsessive-compulsive disorder (OCD) in medication-free children. A total of 44 (22 boys/22 girls) medication-free children with OCD and 40 (23 boys/17 girls) healthy controls were included in this study. The severity of the OCD symptoms were assessed by the Children's Yale-Brown Obsessive-Compulsive Scale and the Maudsley Obsessive-Compulsive Inventory. The Children's Depression Inventory and the Screen for Child Anxiety-Related Emotional Disorders were applied to the children in order to determine depression and anxiety levels. IL-17, IL-12, TGF beta, TNF-alpha, sTNFR1, sTNFR2, IL-1 beta, CCL3, CCL24, CXCL8, and BDNF levels were measured by enzyme-linked immunosorbent assay. Multivariate analysis of covariance (MANCOVA) revealed a significant main effect on both groups for the levels of serum cytokine, chemokine, and BDNF, an effect that was independent of severities of depression and anxiety [Pillai's Trace V = 0.371, F (11, 70) = 3.756, p < 0.001, hp(2) = 0.187]. Analysis of covariance (ANCOVA) indicated that serum TNF-alpha levels were significantly higher in the OCD group than in the control group (p < 0.001). In contrast, serum IL-12 levels were significantly lower in the OCD group than in the control group (p = 0.014). These findings suggest that TNF-alpha and IL-12 may play a role in the pathophysiology of OCD in children. The causal relationship between these proinflammatory cytokines and pediatric OCD requires further investigation.en_US
dc.description.sponsorshipScientific Research Project Coordination Unit of Necmettin Erbakan University [161518001]en_US
dc.description.sponsorshipThe study was financially supported by Scientific Research Project Coordination Unit of Necmettin Erbakan University (Project No: 161518001).en_US
dc.identifier.doi10.1007/s00787-017-1099-3
dc.identifier.endpage984en_US
dc.identifier.issn1018-8827
dc.identifier.issn1435-165X
dc.identifier.issue8en_US
dc.identifier.pmid29302747en_US
dc.identifier.scopus2-s2.0-85040079412en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage977en_US
dc.identifier.urihttps://doi.org/10.1007/s00787-017-1099-3
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11006
dc.identifier.volume27en_US
dc.identifier.wosWOS:000439694000004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Child & Adolescent Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObsessive-Compulsive Disorderen_US
dc.subjectCytokineen_US
dc.subjectChemokineen_US
dc.subjectBrain-Derived Neurotrophic Factoren_US
dc.subjectChildrenen_US
dc.titleCytokine, chemokine and BDNF levels in medication-free pediatric patients with obsessive-compulsive disorderen_US
dc.typeArticleen_US

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