Brain-Derived Neurotrophic Factor Levels in Children with Asthma and Isolated Chronic Cough

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dc.contributor.authorGuc, Belgin Usta
dc.contributor.authorAsilsoy, Suna
dc.contributor.authorCihan, Fatma Goksin
dc.date.accessioned2024-02-23T14:20:58Z
dc.date.available2024-02-23T14:20:58Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractStudies show that neurogenic inflammation is implicated in the pathogenesis of chronic cough. Neurotrophins (NTs) regulate the synthesis of neuropeptides, which cause neurogenic inflammation. There is growing evidence suggesting their involvement in airway inflammation. The role of the brain-derived neurotrophic factor (BDNF), a member of the NT family, is not clear in chronic cough. The aim of this study was to evaluate the role of BDNF in children with nonspecific isolated chronic cough and to compare the differences between patients with asthma and healthy controls. In this case-control study, we included 30 patients with chronic cough (5-15 years) as the patient group. As the control group, 28 asthma patients under control, 30 children with asthma attacks, and 30 healthy children were included. Serum BDNF levels were measured by ELISA in all groups. The median of BDNF levels was 708.12 pg/mL (155-974) in the patient group, 952.94 pg/mL (220-1,018) in the controlled asthma group, 852.09 pg/mL (355-1,036) in the uncontrolled asthma patients, and 572.65 pg/mL (213-818) in the healthy children group. There were differences in the patient group and control groups regarding the BDNF levels (for the patient group and the controlled asthma group, P = 0.0014; for the patient group and the uncontrolled asthma patients, P = 0.0009; for the patient group and healthy children group, P = 0.05). The BDNF levels of asthma patients were statistically different from healthy children (P = 0.0001). Neurogenic inflammation was implicated in the pathogenesis of chronic cough. In patients with chronic cough, high BDNF levels may support the presence of asthma.en_US
dc.description.sponsorshipBaskent University Research Board of Medicine and Health Sciences [KA09/284]en_US
dc.description.sponsorshipThe study was financed by the Baskent University Research Board of Medicine and Health Sciences (Project No: KA09/284).en_US
dc.identifier.doi10.1089/ped.2015.0560
dc.identifier.endpage33en_US
dc.identifier.issn2151-321X
dc.identifier.issn2151-3228
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84961815138en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.1089/ped.2015.0560
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13388
dc.identifier.volume29en_US
dc.identifier.wosWOS:000372457400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofPediatric Allergy Immunology And Pulmonologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleBrain-Derived Neurotrophic Factor Levels in Children with Asthma and Isolated Chronic Coughen_US
dc.typeArticleen_US

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