Prevention of peritendinous adhesions with electrospun poly (lactic acid-co-glycolic acid) (PLGA) bioabsorbable nanofiber: An experimental study

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dc.contributor.authorUyanik, Orkun
dc.contributor.authorPekkoc-Uyanik, Kubra Cigdem
dc.contributor.authorFindik, Siddika
dc.contributor.authorAvci, Ahmet
dc.contributor.authorAltuntas, Zeynep
dc.date.accessioned2024-02-23T14:02:31Z
dc.date.available2024-02-23T14:02:31Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractIn this study, we investigated the application of poly (lactic acid-co-glycolic acid) in the rat Achilles tendon injury model for the prevention or alleviation of peritendinous adhesion and guidance of Achilles tendon regeneration. In the study, 48 rats were used and the rats were randomized by closed envelope method and divided into 4 mating groups in groups of 12. Left Achilles tendons of the non-PLGA-treated control group (groups 1 and 2) were cut and repaired. In the PLGA-treated groups (groups 3 and 4) the left Achilles tendons were cut and repaired, then PLGA bioabsorbable material was wrapped around the repair line. The rats in the 1st and 3rd groups were sacrificed at the end of the 1st month, and the rats in the 2nd and 4th groups at the end of the 2nd month. The degree of tendon adhesion in the Group 3 was lower in comparison with Group 1. Similarly, compared with Group 2, the degree of tendon adhesion in the Group 4 was lower. Inflammatory density, vascularization and fibrosis were higher in the experimental group. When the Group 3 and Group 1, and Group 2 and Group 4 were compared, adhesion length (p = 0.004, p = 0.041), adhesion characteristics (p = 0.049, p = 0.039) and adhesion severity (p = 0.007, p = 0.025) were found have statistically significant tendon healing in the PLGA-treated group, respectively. Significant difference was observed in inflammatory cell density, vascular density and fibrosis for Group 1 and Group 3, (p = 0.027, p = 0.041, p = 0.002), respectively. Similarly, significant difference was observed in inflammatory cell density, vascular density and fibrosis for Group 2 and Group 4, (p = 0.002, p = 0.027, p = 0.011), respectively. As a result, it was considered that poly (lactic acid-co-glycolic acid) material significantly reduces peritendinous adhesions, and this effect could occur with the vascular density, inflammatory density and fibrosis as indicated in histopathological examination. These data suggest that PLGA membrane has good biocompatibility and alleviates tendon adhesion after injury.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects, Turkey [2015,18018]en_US
dc.description.sponsorshipThis work was supported by the Necmettin Erbakan University Scientific Research Projects, Turkey. [grant numbers 2015,18018].en_US
dc.identifier.doi10.1016/j.colsurfb.2021.112181
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.pmid34742023en_US
dc.identifier.scopus2-s2.0-85118501775en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2021.112181
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11747
dc.identifier.volume209en_US
dc.identifier.wosWOS:000718771400003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofColloids And Surfaces B-Biointerfacesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhesionen_US
dc.subjectNanofiber Membranesen_US
dc.subjectNanotechnologyen_US
dc.subjectPoly (Lactic Acid-Co-Glycolic Acid)en_US
dc.subjectTendonen_US
dc.titlePrevention of peritendinous adhesions with electrospun poly (lactic acid-co-glycolic acid) (PLGA) bioabsorbable nanofiber: An experimental studyen_US
dc.typeArticleen_US

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