Antiviral activity of Ribes uva-crispa L. extracts in vitro

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dc.contributor.authorDogan, Hasan Huseyin
dc.contributor.authorDuman, Rustem
dc.contributor.authorDinc, Muhittin
dc.date.accessioned2024-02-23T14:35:24Z
dc.date.available2024-02-23T14:35:24Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractThere is currently no approved vaccine or a useful antiviral drug against respiratory syncytial virus (RSV) that causes viral infection worldwide. Crude plant extracts can be an important resource for the development of new anti-RSV agents. In this study, cytotoxic and anti-RSV effect of the extracts Ribes uva-crispa, which has been known as gooseberry in Turkey and fruits used in the treatment of the various disorders, were evaluated by colorimetric XTT method. Results were expressed as 50% cytotoxicity (CC50), 50% effective concentration (EC50) and selectivity index (SI: CC50 / EC50). Of the tested extracts, the highest antiviral activity was found to be 96.90 mu g/mL EC50 and 11.70 SI from fruit aqueous extract; it was followed by leaf methanol extract (EC50: 2527.41 mu g/mL, SI: 6.55), leaf aqueous extract (EC50: 1093.37 mu g/mL, SI: 1.40) and fruit methanol extract (EC50: 11262.35 mu g/mL, SI: 0.56), respectively. As a result, we can say that these extracts, especially Ribes uva-crispa fruit aqueous and leaf methanol extracts, are worthy of further studies for the development of new and unique anti-RSV drugs.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Projects Coordinating Office [BAP/17401106]en_US
dc.description.sponsorshipThis study was supported by Selcuk University, Scientific Research Projects Coordinating Office (BAP/17401106). Authors would like to thanks for financial support for the project.en_US
dc.identifier.doi10.36721/PJPS.2020.33.3.REG.1173-1178.1
dc.identifier.endpage1178en_US
dc.identifier.issn1011-601X
dc.identifier.issue3en_US
dc.identifier.pmid33191245en_US
dc.identifier.scopus2-s2.0-85090152655en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1173en_US
dc.identifier.urihttps://doi.org/10.36721/PJPS.2020.33.3.REG.1173-1178.1
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16008
dc.identifier.volume33en_US
dc.identifier.wosWOS:000523571000035en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherUniv Karachien_US
dc.relation.ispartofPakistan Journal Of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRibes Uva-Crispaen_US
dc.subjectAqueous Extracten_US
dc.subjectMethanol Extracten_US
dc.subjectAnti-Rsv Activityen_US
dc.titleAntiviral activity of Ribes uva-crispa L. extracts in vitroen_US
dc.typeArticleen_US

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