The Role of Zinc Status on Spatial Memory, Hippocampal Synaptic Plasticity, and Insulin Signaling in icv-STZ-Induced Sporadic Alzheimer's-Like Disease in Rats

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dc.contributor.authorBaltaci, Saltuk Bugra
dc.contributor.authorUnal, Omer
dc.contributor.authorGulbahce-Mutlu, Elif
dc.contributor.authorGumus, Haluk
dc.contributor.authorPehlivanoglu, Suray
dc.contributor.authorYardimci, Ahmet
dc.contributor.authorMogulkoc, Rasim
dc.date.accessioned2024-02-23T13:59:43Z
dc.date.available2024-02-23T13:59:43Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractAlzheimer's disease (AD), especially its sporadic form (sAD), is of multifactorial nature. Brain insulin resistance and disrupted zinc homeostasis are two key aspects of AD that remain to be elucidated. Here, we investigated the effects of dietary zinc deficiency and supplementation on memory, hippocampal synaptic plasticity, and insulin signaling in intracerebroventricular streptozotocin (icv-STZ)-induced sAD in rats. The memory performance was evaluated by Morris water maze. The expression of hippocampal protein and mRNA levels of targets related to synaptic plasticity and insulin pathway was assessed by Western blot and real-time quantitative PCR. We found memory deficits in icv-STZ rats, which were fully recovered by zinc supplementation. Western blot analysis revealed that icv-STZ treatment significantly reduced hippocampal PSD95 and p-GSK3 beta, and zinc supplementation restored the normal protein levels. mRNA levels of BDNF, PSD95, SIRT1, GLUT4, insulin receptor, and ZnT3 were found to be reduced by icv-STZ and reestablished by zinc supplementation. Our data suggest that zinc supplementation improves cognitive deficits and rescues the decline in key molecular targets of synaptic plasticity and insulin signaling in hippocampus caused by icv-STZ induced sAD in rats.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University [19102046]en_US
dc.description.sponsorshipd This study was supported by the Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK; project no. 19102046).en_US
dc.identifier.doi10.1007/s12011-021-02999-2
dc.identifier.endpage4078en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue9en_US
dc.identifier.pmid34727320en_US
dc.identifier.scopus2-s2.0-85118445232en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage4068en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-021-02999-2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11296
dc.identifier.volume200en_US
dc.identifier.wosWOS:000713932800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectBrain Insulin Resistanceen_US
dc.subjectLearning And Memoryen_US
dc.subjectZincen_US
dc.subjectNeurodegenerationen_US
dc.subjectSynaptic Plasticityen_US
dc.titleThe Role of Zinc Status on Spatial Memory, Hippocampal Synaptic Plasticity, and Insulin Signaling in icv-STZ-Induced Sporadic Alzheimer's-Like Disease in Ratsen_US
dc.typeArticleen_US

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