Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study

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dc.contributor.authorDuman, Taskin
dc.contributor.authorCinar, Nilgun
dc.contributor.authorUluduz, Derya
dc.contributor.authorDomac, Fusun Mayda
dc.contributor.authorOzturk, Serefnur
dc.contributor.authorYayla, Vildan
dc.contributor.authorKarahan, Ali Yavuz
dc.date.accessioned2024-02-23T14:29:36Z
dc.date.available2024-02-23T14:29:36Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjectives: Headache is the most common complaint in cerebral venous sinus thrombosis (CVST) and it may sometimes be the only symptom in these patients. This retrospective and prospective study was an investigation of any differences in terms of clinical risk factors, radiological findings, or prognosis in patients with CVST who presented with isolated headache (IH) and cases with other concomitant findings (non-isolated headache [NIH]). Methods: A total of 1144 patients from a multicenter study of cerebral venous sinus thrombosis ( VENOST study) were enrolled in this research. The demographic, biochemical, clinical, and radiological aspects of 287 IH cases and 857 NIH cases were compared. Results: There were twice as many women as men in the study group. In the IH group, when gender distribution was evaluated by age group, no statistically significant difference was found. The onset of headache was frequently subacute and chronic in the IH group, but an acute onset was more common in the NIH group. Other neurological findings were observed in 29% of the IH group during follow-up. A previous history of deep, cerebral, or other venous thromboembolism was less common in the IH group than in the NIH group. Transverse sinus involvement was greater in the IH group, whereas sagittal sinus involvement was greater in the NIH group. The presence of a plasminogen activator inhibitor (PAI) mutation was significantly greater in the IH group. Conclusion: IH and CVST should be kept in mind if a patient has subacute or chronic headache. PAI, which has an important role in thrombolytic events, may be a risk factor in CVST. Detailed hematological investigations should be considered. Additional studies are needed.en_US
dc.identifier.doi10.14744/agri.2020.77698
dc.identifier.endpage14en_US
dc.identifier.issn1300-0012
dc.identifier.issue1en_US
dc.identifier.pmid34254656en_US
dc.identifier.scopus2-s2.0-85105266958en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://doi.org/10.14744/agri.2020.77698
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14756
dc.identifier.volume33en_US
dc.identifier.wosWOS:000644197800002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofAgri-The Journal Of The Turkish Society Of Algologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerebral Venous Sinus Thrombosisen_US
dc.subjectCerebrovascular Diseaseen_US
dc.subjectHeadacheen_US
dc.titleHeadache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST studyen_US
dc.typeArticleen_US

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