Influence of aluminum salts on COVID-19 infected patients

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dc.contributor.authorDemir, Ali
dc.contributor.authorErayman, Ibrahim
dc.contributor.authorDogan, Oguz
dc.contributor.authorKekilli, Murat
dc.date.accessioned2024-02-23T14:37:24Z
dc.date.available2024-02-23T14:37:24Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractBackground/aim: Based on the antiviral and antibacterial properties of aluminum salts, we aimed to find out the influence of aluminum salts on COVID-19 infected patients. Materials and methods: We performed an observational retrospective cohort study which includes the patients diagnosed as COVID-19 and received aluminum salts in addition to actual treatments during hospitalization as the treatment group (Alum Group). Patients who received standard COVID-19 treatment protocols in the Infectious Diseases Clinics were included as the Control Group. Clinical findings, laboratory parameters, length of stay, survival, radiological follow-up, intensive care and mechanical ventilation needs, the presence of comorbidity, polymerase chain reaction (PCR) tests, symptoms, symptom recovery times, hospital stay times, treatment protocols, and clinical presence of pneumonia were examined in all patients. Advanced chemical composition analyzes of existing aluminum salts were also performed. Results: A total of 109 patients, 54 in the alum group and 55 in the control group, were included in the study. None of the patients in the aluminum group developed side effects due to the intake of aluminum salt. Survival status was significantly different between the two groups as there were 5 loss in the Control Group and none in the Alum Group (P = 0.023). The symptom recovery time was significantly shorter in the Alum Group; 2 (1-3) vs. 1 (1-2) days, P= 0.003. According to the paired samples analyses of the comparison between hospitalization and discharge, CRP levels significantly drops in the Alum Group (from 54.09 to 27, P = 0.001) but not in the Control Group. The drop was significantly same for the lactate dehydrogenase (LDH) and procalcitonin levels with P = 0.001. Conclusion: It has been observed that aluminum salts have beneficial effects in COVID-19 infected cases. Considering the low systemic toxicity of intermittent oral intake of aluminum salts as food supplements and the fact that pandemic control is still not achieved, the use of aluminum salts is promising.en_US
dc.identifier.doi10.3906/sag-2009-140
dc.identifier.endpage1780en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue8en_US
dc.identifier.pmid33315350en_US
dc.identifier.scopus2-s2.0-85098736382en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1771en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2009-140
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16090
dc.identifier.volume50en_US
dc.identifier.wosWOS:000600735500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronavirus (Covid-19)en_US
dc.subjectAluminum Saltsen_US
dc.titleInfluence of aluminum salts on COVID-19 infected patientsen_US
dc.typeArticleen_US

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