Screening for Latent Tuberculosis in Children With Immune-Mediated Inflammatory Diseases Treated With Anti-Tumor Necrosis Factor Therapy: Comparison of Tuberculin Skin and T-SPOT Tuberculosis Tests

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dc.contributor.authorGirit, Saniye
dc.contributor.authorAtabek, Ayse Ayzit
dc.contributor.authorSenol, Ebru
dc.contributor.authorKockar Kizilirmak, Tuba
dc.contributor.authorPekcan, Sevgi
dc.contributor.authorGoktas, Safak
dc.contributor.authorOktem, Sedat
dc.date.accessioned2024-02-23T14:41:51Z
dc.date.available2024-02-23T14:41:51Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractObjectives: This study aims to analyze the coherence between T-SPOT tuberculosis test (T-SPOT.TB) and tuberculin skin test (TST) with different cut-off values in screening latent tuberculosis infection (LTBI) both prior to and at the sixth month of anti-tumor necrosis factor (anti-TNF) treatment. Patients and methods: This prospective multicentric study included 57 children (34 girls, 23 boys, mean age 12.4 +/- 3.9 years; range, 6 to 18 years) diagnosed with immune-mediated inflammatory diseases (IMIDs) evaluated with TST and T-SPOT.TB for screening LTBI both prior to and at the sixth month of treatment with anti-TNF agents. Coherence between two tests was analyzed for TST cut-off values suggested by the local guidelines and also for different possible cut-off values of TST. Results: Tuberculin skin test was positive (>= 5 mm) in 28.1% (n=16) of patients in the screening prior to treatment and in 33.3% (n=19) at the sixth month of treatment. T-SPOT.TB test was positive in 8.8% (n=5) of patients both prior to and at the sixth month of treatment. Coherence between two tests was poor or fair when compared with all possible TST cut-off values both prior to and at the sixth month of anti-TNF therapy. Conclusion: Our results show poor coherence between T-SPOT.TB and TST for all possible cut- off values of TST. Thus, using both tests would be beneficial in screening LTBI until further studies bring new evidence on the subject.en_US
dc.identifier.doi10.5606/ArchRheumatol.2020.7294
dc.identifier.endpage28en_US
dc.identifier.issn2148-5046
dc.identifier.issn1309-0283
dc.identifier.issue1en_US
dc.identifier.pmid32637916en_US
dc.identifier.scopus2-s2.0-85088380238en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org/10.5606/ArchRheumatol.2020.7294
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17039
dc.identifier.volume35en_US
dc.identifier.wosWOS:000520407500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish League Against Rheumatismen_US
dc.relation.ispartofArchives Of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChilden_US
dc.subjectImmune System Diseaseen_US
dc.subjectInterferon-Gamma Release Assayen_US
dc.subjectLatent Tuberculosisen_US
dc.subjectTuberculin Skin Testen_US
dc.titleScreening for Latent Tuberculosis in Children With Immune-Mediated Inflammatory Diseases Treated With Anti-Tumor Necrosis Factor Therapy: Comparison of Tuberculin Skin and T-SPOT Tuberculosis Testsen_US
dc.typeArticleen_US

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