Effects of Carvacrol on Survival, Mesenteric Blood Flow, Aortic Function and Multiple Organ Injury in a Murine Model of Polymicrobial Sepsis

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dc.contributor.authorOzer, Erdem Kamil
dc.contributor.authorGoktas, Mustafa Tugrul
dc.contributor.authorToker, Aysun
dc.contributor.authorBariskaner, Hulagu
dc.contributor.authorUgurluoglu, Ceyhan
dc.contributor.authorIskit, Alper Bektas
dc.date.accessioned2024-02-23T13:56:10Z
dc.date.available2024-02-23T13:56:10Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractCarvacrol (CRV) has strong cytoprotective, antioxidant, and anti-inflammatory properties. We aimed to demonstrate the possible protective effects of CRV on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in a murine model of polymicrobial sepsis induced by cecal ligation and puncture (CLP). Wistar rats were allocated into the following four groups: Sham, CLP, Sham + CRV, and CLP + CRV. The animals were orally administered with CRV (80 mg/kg/day) or vehicle (corn oil; 1 mL/kg/day) for 7 days. At the eighth day, Sham or CLP procedure was applied. Twenty hours after the operations, MBF and contractile responses of isolated aortic preparations to phenylephrine were measured. Tissue samples were obtained for biochemical and histopathological assessments. Additionally, survival rates were recorded throughout 96 h. CRV administration improved the mesenteric perfusion, contractile function of aorta, and survival after CLP. CRV substantially prevented the elevations in the levels of LDH, BUN, Cr, and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6) but could not prevent the elevations of AST and ALT after CLP. The decreased liver, kidney, and spleen glutathione levels and increased liver, kidney, lung, and spleen malondialdehyde levels induced by CLP were substantially restored by CRV. Also, histopathological protective effects of CRV on multiple organ damage due to CLP were observed. CRV possesses strong ameliorative effects on sepsis due to its protective effects on mesenteric perfusion and aortic function and its antioxidative and anti-inflammatory effects.en_US
dc.description.sponsorshipTurkish Academy of Sciences [EA-TUBA-GEBIP/2001-2-11]; Selcuk University Scientific Research Coordination [15401078]en_US
dc.description.sponsorshipAlper B. Iskit has been supported by the Turkish Academy of Sciences, in the framework of the Young Scientist Award Program (EA-TUBA-GEBIP/2001-2-11). This study was supported by Selcuk University Scientific Research Coordination (No: 15401078).en_US
dc.identifier.doi10.1007/s10753-017-0605-6
dc.identifier.endpage1663en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue5en_US
dc.identifier.pmid28646428en_US
dc.identifier.scopus2-s2.0-85021226614en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1654en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-017-0605-6
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11100
dc.identifier.volume40en_US
dc.identifier.wosWOS:000409472600017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarvacrolen_US
dc.subjectSepsisen_US
dc.subjectSurvivalen_US
dc.subjectVascular Reactivityen_US
dc.subjectMesenteric Perfusionen_US
dc.subjectMultiple Organ Functionen_US
dc.titleEffects of Carvacrol on Survival, Mesenteric Blood Flow, Aortic Function and Multiple Organ Injury in a Murine Model of Polymicrobial Sepsisen_US
dc.typeArticleen_US

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