STK4 deficiency and EBV-associated lymphoproliferative disorders, emphasis on histomorphology, and review of literature

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dc.contributor.authorSaglam, Arzu
dc.contributor.authorCagdas, Deniz
dc.contributor.authorAydin, Burca
dc.contributor.authorKeles, Sevgi
dc.contributor.authorReisli, Ismail
dc.contributor.authorArslankoz, Sehbal
dc.contributor.authorKatipoglu, Kubra
dc.date.accessioned2024-02-23T13:43:49Z
dc.date.available2024-02-23T13:43:49Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractAberrations of the STK4 gene in humans result in an autosomal recessively inherited primary immunodeficiency. We identified three patients with STK4 deficiency who had presented to our hospital and reviewed their biopsy samples with the goal of detailing the characteristics of STK4 deficiency from a pathology perspective. Case 1 was a 20-year-old male who presented with cervical and supraclavicular lymphadenopathy which showed plasmacytic hyperplasia and a concurrent bronchial mass, with AA amyloidosis and EBV-associated polymorphic lymphoproliferative disorder (LPD) resembling polymorphic post-transplant LPD. The second case was an 8-year-old girl with abdominal lymphadenopathy; biopsy revealed a complex lymphoproliferation which consisted of EBV-associated polymorphic LPD resembling polymorphic post-transplant LPD, plasmacytic hyperplasia, granulomatous reaction, and a CD4- and PD-1-positive clonal T cell proliferation. The third was a 15-year-old girl with a laryngeal mass, representing a high-grade B cell lymphoma with prominent plasmacytic differentiation. Our cases emphasize the complex and challenging histopathology of lymphoid proliferations in patients with STK4 deficiency.en_US
dc.identifier.doi10.1007/s00428-021-03147-w
dc.identifier.endpage401en_US
dc.identifier.issn0945-6317
dc.identifier.issn1432-2307
dc.identifier.issue2en_US
dc.identifier.pmid34604912en_US
dc.identifier.scopus2-s2.0-85116098907en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage393en_US
dc.identifier.urihttps://doi.org/10.1007/s00428-021-03147-w
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10939
dc.identifier.volume480en_US
dc.identifier.wosWOS:000702984700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofVirchows Archiven_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStk4en_US
dc.subjectPlasma Cellen_US
dc.subjectImmunodeficiencyen_US
dc.subjectLymphomaen_US
dc.subjectEbven_US
dc.subjectLymphoproliferative Disorderen_US
dc.titleSTK4 deficiency and EBV-associated lymphoproliferative disorders, emphasis on histomorphology, and review of literatureen_US
dc.typeReview Articleen_US

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