Evaluation of the effect of hyperbaric oxygen therapy on hypertrophic scar formation in a rabbit ear model: An experimental study

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dc.contributor.authorInce, Bilsev
dc.contributor.authorIsmayilzade, Majid
dc.contributor.authorArslan, Abdullah
dc.contributor.authorOltulu, Pembe
dc.contributor.authorBaycar, Zikrullah
dc.contributor.authorDadaci, Mehmet
dc.date.accessioned2024-02-23T14:24:06Z
dc.date.available2024-02-23T14:24:06Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractHypertrophic scar is a disease with complicated treatment methods. Although there are numerous studies in the literature definitive therapy has not been reported yet. In this study, we aimed to evaluate the short and long-term effects of HBOT on hypertrophic scar formation in a rabbit ear model. A total of 20 male New Zealand rabbits weighing 2.1 to 2.4 kg were used in this study. The rabbits in group 2 were exposed to hyperbaric oxygen treatment for 7 days starting from the first day following biopsy punch, while no extra treatment was applied to the rabbits in group 1. Macroscopic scar thickness, histopathological parameters and HI were assessed in both of the 30th day and 60th day scars. Scar thickness was found significantly less in the scars of the rabbits exposed to HBOT (P < .05). And less dermal hypertrophy was also found in HI results of group 2.(P approximate to .022) There were differences between groups in terms of inflammation, vascularization and density of collagen fibrils. HBOT applied for 7 days from the first day of wound formation has both short and long-term effects on the triggering factors of hypertrophic scar, especially on inflammation.en_US
dc.identifier.doi10.1111/dth.14146
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue6en_US
dc.identifier.pmid32761727en_US
dc.identifier.scopus2-s2.0-85090136682en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/dth.14146
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13822
dc.identifier.volume33en_US
dc.identifier.wosWOS:000565410200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Hindawien_US
dc.relation.ispartofDermatologic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDermal Hypertrophyen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectHypertrophic Scaren_US
dc.subjectInflammationen_US
dc.subjectRabbit Ear Modelen_US
dc.titleEvaluation of the effect of hyperbaric oxygen therapy on hypertrophic scar formation in a rabbit ear model: An experimental studyen_US
dc.typeArticleen_US

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