Caspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control study

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dc.contributor.authorEyuboglu, Tugba Sismanlar
dc.contributor.authorAslan, Ayse Tana
dc.contributor.authorGursoy, Tugba Ramasli
dc.contributor.authorPekcan, Sevgi
dc.contributor.authorKose, Mehmet
dc.contributor.authorHangul, Melih
dc.contributor.authorAral, Latife Arzu
dc.date.accessioned2024-02-23T13:43:50Z
dc.date.available2024-02-23T13:43:50Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe exact immunological mechanisms of post infectious bronchiolitis obliterans (PIBO) in childhood are not fully known. It has been shown that the inflammasome and IL-18 pathway play important roles in the pathogenesis of lung fibrosis. We aimed to investigate the role of caspase-1, IL-18, and IL-18 components in PIBO. From January to May 2020, children with PIBO, children with history of influenza infection without PIBO, and healthy children were asked to participate in the study in three pediatric pulmonology centers. Serum caspase-1, IL-18, IL-18BP, IL-18R, and INF-gamma levels were measured by ELISA and compared between the 3 groups. There were 21 children in the PIBO group, 16 children in the influenza group, and 39 children in the healthy control group. No differences in terms of age and gender between the 3 groups were found. IL-18 and IL-18BP levels were higher in the healthy control group (p = 0.018, p = 0.005, respectively). IL- 18R was higher in the PIBO group (p = 0.001) and caspase-1 was higher in the PIBO and influenza group than the healthy control group (p = 0.002). IFN-gamma levels did not differ between the 3 groups. IL-18BP/IL-18 was higher in the influenza group than the PIBO group and the healthy control group (p = 0.003). Conclusions: Caspase-1 level was increased in patients with PIBO which suggests that inflammasome activation may have a role in fibrosis; however, IL-18 level was found to be low. Mediators other than IL-18 may be involved in the inflammatory pathway in PIBO. Further immunological studies investigating inflammasome pathway are needed for PIBO with chronic inflammation.en_US
dc.description.sponsorshipGazi University Scientific Research Projects Coordination Unit [01/2020-16]en_US
dc.description.sponsorshipThis work has been supported by Gazi University Scientific Research Projects Coordination Unit under grant number 01/2020-16.en_US
dc.identifier.doi10.1007/s00431-022-04528-2
dc.identifier.endpage3101en_US
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue8en_US
dc.identifier.pmid35705877en_US
dc.identifier.scopus2-s2.0-85131939457en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3093en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-022-04528-2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10942
dc.identifier.volume181en_US
dc.identifier.wosWOS:000811409600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaspase-1en_US
dc.subjectChildrenen_US
dc.subjectIl-18en_US
dc.subjectPost Infectious Bronchiolitis Obliteransen_US
dc.titleCaspase-1 and interleukin-18 in children with post infectious bronchiolitis obliterans: a case-control studyen_US
dc.typeArticleen_US

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