Comparison of the Efficacy of Three Natural Surfactants in Preterm Turkish Newborns with Respiratory Distress Syndrome

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dc.contributor.authorYilmaz, Fatma Hilal
dc.contributor.authorTarakci, Nuriye
dc.contributor.authorGultekin, Nazli Dilay
dc.contributor.authorYucel, Mehmet
dc.contributor.authorKececi, Ramazan
dc.contributor.authorOzturk, Elif Nur Yildirim
dc.contributor.authorAltunhan, Huseyin
dc.date.accessioned2024-02-23T14:38:10Z
dc.date.available2024-02-23T14:38:10Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractAim: To determine the efficacy of three natural surfactant preparations in our community and the short- and long-term results of these on preterm infants. Materials and Methods: This was a retrospective research on 193 premature babies with respiratory distress syndrome (RDS). The patients were divided into three groups, each of which received one of three surfactants: Group 1; beractant (100 mg/kg); group 2; poractant alfa (first dose of 200 mg/kg, recurrent doses of 100 mg/kg); group 3; calfactant (100 mg/kg). The groups were compared according to demographic characteristics, 1- and 5-minute Apgar scores, weight percentiles by gestational week, presence of pulmonary hemorrhage, surfactant dose repetition, air leak, bronchopulmonary dysplasia (BPD), stage of intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), hemodynamically significantpatent ductus arteriosus (hs-PDA) and its medical or surgical treatment, retinopathy of premature (ROP) and its treatment, sepsis, ventilation time (both non-invasive and invasive), free oxygen need time, time to start full enteral feeding, discharge time, and mortality. Results: A total of 193 preterm infants with a mean gestational age of 28.9 +/- 3.1 weeks and mean birth weight of 1,190.4 +/- 504.3 grams were included in this study. The neonates were allocated into three different groups randomly, namely group-1 (n=77), group-2 (n=59), and group-3 (n=57). There were no differences in the clinical and demographic features of the groups. The incidence of pulmonary hemorrhage, surfactant dose repetition, air leak, ventilation time for both non-invasive and invasive, free oxygen need time, hs-PDA and surgical treatment of PDA, BPD, NEC (>= stage II), IVH (>stage III), ROP, time to start full enteral feeding, and discharge time were similar between the study groups. The sepsis and mortality rates were lower in group 3 compared to groups 1 and 2 (p=0.015, p=0.001). Conclusion: In this study, beractant, proctant alfa and calfactant had clinically similar efficacy in patients with RDS.en_US
dc.identifier.doi10.4274/jpr.galenos.2020.04864
dc.identifier.endpage130en_US
dc.identifier.issn2147-9445
dc.identifier.issue2en_US
dc.identifier.startpage124en_US
dc.identifier.urihttps://doi.org/10.4274/jpr.galenos.2020.04864
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16401
dc.identifier.volume8en_US
dc.identifier.wosWOS:000656055300005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal Of Pediatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRespiratory Distressen_US
dc.subjectNeonateen_US
dc.subjectSurfactanten_US
dc.subjectTurkeyen_US
dc.titleComparison of the Efficacy of Three Natural Surfactants in Preterm Turkish Newborns with Respiratory Distress Syndromeen_US
dc.typeArticleen_US

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