GPER-1 in chronic hepatitis B

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dc.contributor.authorKandemir, Bahar
dc.contributor.authorAtes, Selma
dc.contributor.authorKurutas, Ergul Belge
dc.contributor.authorDurduran, Yasemin
dc.contributor.authorErayman, Ibrahim
dc.contributor.authorBitirgen, Mehmet
dc.date.accessioned2024-02-23T14:20:42Z
dc.date.available2024-02-23T14:20:42Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractEstrogen has a significant role in regulating cell proliferation, growth, migration, aging, and many disease states. Estrogen shows its effects through estrogen receptors alpha, beta, and G protein-coupled estrogen receptor 1 (GPER1). The aim of this study is to evaluate serum GPER1 levels and its relationship with fibrosis score in chronic hepatitis B patients. The cases were selected from two university hospitals and consisted of patients who had not previously been treated for hepatitis B, were over 18. Quantitative sandwich enzyme immunoassay technique was used for measuring the serum levels of GPER1. The data evaluated were analyzed by using the statistical tests. Out of the 65 cases; 26 (40%) had hepatitis B, 39 (60%) were controls. Patients underwent liver biopsy. GPER1 levels were significantly high in Hepatitis B group (p < 0.001). Out of the 26 hepatitis B patients; 21(80,8%) had low-stage fibrosis, 5(19,2%) had high-stage fibrosis. When the GPER1 level was >= 017600000 the sensitivity, specificity, positive predictive value, and negative predictive value for the hepatitis B patients were found to be 96%, 87,7%, 96%, and 92,8%, respectively. GPER levels have shown high expression in patients with chronic hepatitis B.en_US
dc.identifier.doi10.1080/16878507.2020.1762527
dc.identifier.endpage551en_US
dc.identifier.issn1687-8507
dc.identifier.issue1en_US
dc.identifier.startpage546en_US
dc.identifier.urihttps://doi.org/10.1080/16878507.2020.1762527
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13255
dc.identifier.volume13en_US
dc.identifier.wosWOS:000536555400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Radiation Research And Applied Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Hepatitisen_US
dc.subjectG Protein Coupled Estrogen Receptor (Gper)en_US
dc.subjectEstrogenen_US
dc.titleGPER-1 in chronic hepatitis Ben_US
dc.typeArticleen_US

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