Can altered colostrum miRNA expression profile after cesarean delivery be a risk factor for autoimmune diseases?

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dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorOnmaz, Duygu Eryavuz
dc.contributor.authorAltunhan, Huseyin
dc.contributor.authorIlhan, Merve
dc.date.accessioned2024-02-23T14:24:01Z
dc.date.available2024-02-23T14:24:01Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractProblem The cesarean section (CS) rate has increased significantly in North America, Western Europe, and Latin America. However, it has been reported that the incidence of inflammatory and autoimmune diseases such as asthma and type 1 diabetes increased in parallel with CS in these countries. Our aim was to investigate the expression level of miRNAs associated with inflammatory response and autoimmune diseases in colostrum samples and contribute to elucidating the role of CS in the pathogenesis of immune system-related diseases. Method of study Colostrum samples were taken from voluntary mothers who had 40 normal and 50 cesarean births. miRNAs were extracted from colostrums and detected to miRNA expression profiling (eighty-four miRNAs) by quantitative real-time PCR with the Fluidigm integrated microfluidic circuit technology. Results There was a statistically significant change in the expression levels of 17 miRNAs in the colostrums of mothers who had normal and cesarean delivery (p < .05), and all of miRNAs were upregulated in the colostrums of mothers who have had cesarean delivery. Conclusion Our best knowledge is that the study we conducted was the first to investigate the effect of delivery method (CS or normal) on the miRNA profile of colostrum. Cesarean delivery is a potential risk factor for inflammatory and immune system-related diseases in children due to dysregulation in miRNA expression.en_US
dc.description.sponsorshipNecmettin Erbakan Universitesi [181218016]en_US
dc.description.sponsorshipNecmettin Erbakan Universitesi, Grant/ Award Number: 181218016en_US
dc.identifier.doi10.1111/aji.13472
dc.identifier.issn1046-7408
dc.identifier.issn1600-0897
dc.identifier.issue4en_US
dc.identifier.pmid34080731en_US
dc.identifier.scopus2-s2.0-85107033097en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/aji.13472
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13776
dc.identifier.volume86en_US
dc.identifier.wosWOS:000657361000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAmerican Journal Of Reproductive Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCesarean Sectionen_US
dc.subjectNormal Birthen_US
dc.subjectMirnaen_US
dc.subjectAutoimmune Diseaseen_US
dc.subjectInflammationen_US
dc.titleCan altered colostrum miRNA expression profile after cesarean delivery be a risk factor for autoimmune diseases?en_US
dc.typeArticleen_US

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