Prognostic Importance of Ki-67 Labeling Index in Grade II Glial Tumors

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dc.contributor.authorKanyilmaz, Gul
dc.contributor.authorOnder, Hatice
dc.contributor.authorAktan, Meryem
dc.contributor.authorKoc, Mehmet
dc.contributor.authorBora, Huseyin
dc.contributor.authorKarahacioglu, Eray
dc.contributor.authorErkal, Haldun Sukru
dc.date.accessioned2024-02-23T14:41:37Z
dc.date.available2024-02-23T14:41:37Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE To date, several methods have been identified for predicting the prognostic subgroups of grade II gliomas; however, these methods have some limitations in predicting survival. So, we aimed to determine the predictive role of Ki-67 labeling, index (LI) on survival. METHODS Between 1995 and 2011, patients with grade II, gliomas were retrospectively analyzed. All patients received radiotherapy (RT). RESULTS This study included 78 patients with median 44 (range, 6-137) months follow-up. Patients aged >= 40 years had a poorer overall survival (OS) than those aged <10 years (p=0.04). Patients with gross total resection/ subtotal resection had a longer OS than those with biopsy/partial resection (p=0.001). If the disease had recurrence or progression during the follow-up period, the patients had a poorer OS (p=0.01). Patients with a Ki-67 LI >= 4% had a poorer OS than those with Ki-67 LI < 4%(p=0.001). The extent of resection, recurrence, or progression, and Ki-67 LI >= 4% were the independent prognostic factors for OS. CONCLUSION In our opinion, Ki-67 LI is an important prognostic factor for grade II gliomas, hut it cannot be used as a diagnostic measure alone. It must be used in combination with the other prognostic factors.en_US
dc.identifier.doi10.5505/tjo.2018.1752
dc.identifier.endpage53en_US
dc.identifier.issn1300-7467
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85048292217en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://doi.org/10.5505/tjo.2018.1752
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16935
dc.identifier.volume33en_US
dc.identifier.wosWOS:000436167800002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal Of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGrade Ii Glial Tumorsen_US
dc.subjectKi-67 Labeling Indexen_US
dc.subjectPrognostic Factorsen_US
dc.subjectRadiotherapyen_US
dc.subjectSurvivalen_US
dc.titlePrognostic Importance of Ki-67 Labeling Index in Grade II Glial Tumorsen_US
dc.typeArticleen_US

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