Geraniol attenuates hydrogen peroxide-induced liver fatty acid alterations in male rats

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dc.contributor.authorOzkaya, Ahmet
dc.contributor.authorSahin, Zafer
dc.contributor.authorGorgulu, Ahmet Orhan
dc.contributor.authorYuce, Abdurrauf
dc.contributor.authorCelik, Sait
dc.date.accessioned2024-02-23T14:41:32Z
dc.date.available2024-02-23T14:41:32Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractBackground: Hydrogen peroxide (H2O2) is an oxidant agent and this molecule naturally occurs in the body as a product of aerobic metabolism. Geraniol is a plant-derived natural antioxidant. The aim of this study was to determine the role of geraniol on hepatic fatty acids alterations following H2O2-induced oxidative stress in male rats. Methods: After randomization, male Wistar rats were divided into four groups (n = 7 each group). Geraniol (50 mg/kg, dissolved in corn oil) and H2O2 (16 mg/kg, dissolved in distilled water) were administered by an intraperitoneal injection. Administrations were performed during 30 days with 1-day interval. Results: Administration of H2O2 resulted with a significant increase in malondialdehyde (MDA) and a significant decrease in glutathione (GSH) peroxidase glutathione level; geraniol restored its effects on liver. However, hepatic catalase (CAT) activities were significantly higher in H2O2, geraniol, and geraniol+ H2O2 groups than control group. The ratio of hepatic total saturated fatty acids increased in H2O2-treated animals compared with control. In addition, hepatic total unsaturated fatty acids reduced in H2O2 group compared with control. The percentages of both hepatic total saturated and unsaturated fatty acids were not different between geraniol+ H2O2 and control groups. Conclusions: H2O2-induced oxidative stress may affect fatty acid composition in liver and body. Geraniol can partly restore oxidative hepatic damage because it cannot completely reverse the H2O2 -induced increase in hepatic CAT activities. Moreover, this natural compound can regulate hepatic total saturated and unsaturated fatty acids percentages against H2O2-induced alterations.en_US
dc.description.sponsorshipScientific Research Projects Unit of Adiyaman University (ADYUBAP) project [FEFBAP/2012-0001]en_US
dc.description.sponsorshipWe thank Dr. Z. Isik Solak Gormus for technical assistance and reviewing the use of English in the manuscript. This research was supported by the Scientific Research Projects Unit of Adiyaman University (ADYUBAP) project, number FEFBAP/2012-0001.en_US
dc.identifier.doi10.5455/jice.20160928012410
dc.identifier.endpage35en_US
dc.identifier.issn2146-8397
dc.identifier.issue1en_US
dc.identifier.pmid28163957en_US
dc.identifier.scopus2-s2.0-85014132451en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.5455/jice.20160928012410
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16892
dc.identifier.volume6en_US
dc.identifier.wosWOS:000396585800005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEjmanager Llcen_US
dc.relation.ispartofJournal Of Intercultural Ethnopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFatty Acidsen_US
dc.subjectGeraniolen_US
dc.subjectHydrogen Peroxideen_US
dc.subjectLiveren_US
dc.subjectOxidative Stressen_US
dc.titleGeraniol attenuates hydrogen peroxide-induced liver fatty acid alterations in male ratsen_US
dc.typeArticleen_US

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