Local effects of epidermal growth factor on the wound healing in esophageal anastomosis: An experimental study

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dc.contributor.authorAdam, Ayse Bulbul
dc.contributor.authorOzdamar, Mustafa Yasar
dc.contributor.authorEsen, Haci Hasan
dc.contributor.authorGunel, Engin
dc.date.accessioned2024-02-23T14:03:12Z
dc.date.available2024-02-23T14:03:12Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractObjective: In this study with the experimental model of primary repair of esophageal atresia(EA), we investigated the effects of the epidermal growth factor(EGF) on wound healing in the anastomosis of EA. Materials and methods: Forty rabbits that were performed a resection of a 1-cm segment of the cervical esophagus followed by the end-to-end anastomosis were divided into four groups. Group I (7-day group) and III (21-day group), the control groups, had no EGF applied to the anastomosis. In group II (7-day group) and group III (21-day group), all around the anastomoses were locally covered with 100 mu g/kg EGF. Group 1, 2 and 3, 4 were sacrificed on the 7th and 21st day, respectively. We investigated and compared with bursting pressure, vascularization around the anastomotic line by histopathology, inflammation, and fibroblast granulation as well as hydroxyproline level by biochemical. Results: No significant difference was found at vascularization and inflammation between all of the groups (p > 0.05). Considering the critical parameters of the groups, at bursting pressure difference was found between group 1 and 2 as well as 3 and (p < 0.05). At fibroblast granulation and hydroxyproline level, no difference was found between group 1 and 2 (p > 0.05) but the difference between group 3 and 4 (p < 0.05). Conclusion: EGF might be useful in preventing anastomotic leakage of esophageal atresia in primary anastomosis of esophageal atresia by accelerating wound healing process and increasing the stability of the anastomotic line. (C) 2017 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipNecmettin Erbakan University Institution of Scientific Research Project [09202074]en_US
dc.description.sponsorshipThis work was supported by the Necmettin Erbakan University Institution of Scientific Research Projects [grant numbers, 09202074].en_US
dc.identifier.doi10.1016/j.ijporl.2017.05.013
dc.identifier.endpage12en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.pmid28688571en_US
dc.identifier.scopus2-s2.0-85019768640en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage8en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2017.05.013
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12016
dc.identifier.volume99en_US
dc.identifier.wosWOS:000406729400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidermal Growth Factoren_US
dc.subjectEsophageal Atresia.en_US
dc.subjectWound Healingen_US
dc.subjectAnastomotic Leakageen_US
dc.titleLocal effects of epidermal growth factor on the wound healing in esophageal anastomosis: An experimental studyen_US
dc.typeArticleen_US

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