Anticancer, antimicrobial, spectral, voltammetric and DFT studies with Cu(II) complexes of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its N(4)-substituted derivatives

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dc.contributor.authorTurkkan, Ercan
dc.contributor.authorSayin, Ulku
dc.contributor.authorErbilen, Nesibe
dc.contributor.authorPehlivanoglu, Suray
dc.contributor.authorErdogan, Gokce
dc.contributor.authorTasdemir, Halil Ugur
dc.contributor.authorSaf, Ahmet Ozgur
dc.date.accessioned2024-02-23T14:13:01Z
dc.date.available2024-02-23T14:13:01Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractNew copper complexes of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its N(4)-substituted derivatives were synthesized and characterized by theoretical DFT studies and experimental UV-Vis, FT-IR, EPR spectral analysis, cyclic voltammetry, magnetic susceptibility and conductivity measurements. The DFT calculation results have been used to predict and interpret the experimental results. The geometric parameter G within the range of 7.61-7.86 for all complexes confirms the mononuclear nature of the complexes. The EPR, UV-Vis, DFT studies and obtained bonding parameters show that all the complexes have square planar geometry and their M-L bonds have strong ionic and some in-plane a-bond character. In addition, the experimental and DFT studies showed that HOMO and LUMO energy levels of the complexes may present good electron transporting properties. Also, the investigated Cu(II) complexes were tested for biological activity, proving both in vitro antibacterial and anticancer activity. The complexes exhibited antibacterial activity against Gram positive bacteria S. aureus while exhibiting no activities against gram negative bacteria E. toll and S. gallinarum. The f parameters obtained experimentally by EPR support the antimicrobial activity properties results of the complexes. The evaluations of potential anticancer activity of these complexes were carried out against highly metastatic MDA-MB-231 breast adenocarcinoma cell line by MTT assay. Our results suggest that all tested copper complexes have high cytotoxic effects with the range of 1.76-3.53 mu M IC50 values in vitro. These copper complexes could be considered as potential anticancer agents to counteract drug resistance of metastatic cancer cells. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects (BAP) of Necmettin Erbakan Universityen_US
dc.description.sponsorshipThe authors are grateful to the Scientific Research Projects (BAP) of Necmettin Erbakan University for financial support.en_US
dc.identifier.doi10.1016/j.jorganchem.2016.12.020
dc.identifier.endpage35en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-85008956970en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2016.12.020
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12249
dc.identifier.volume831en_US
dc.identifier.wosWOS:000394473300004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal Of Organometallic Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiosemicarbazoneen_US
dc.subjectCopper(Ii) Complexesen_US
dc.subjectEpren_US
dc.subjectFt-Iren_US
dc.subjectCyclic Voltammetryen_US
dc.subjectAntimicrobial And Anticancer Activityen_US
dc.subjectDften_US
dc.titleAnticancer, antimicrobial, spectral, voltammetric and DFT studies with Cu(II) complexes of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its N(4)-substituted derivativesen_US
dc.typeArticleen_US

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