Demodex positive discoid lupus erythematosus: Is it a separate entity or an overlap syndrome?

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dc.contributor.authorDursun, Recep
dc.contributor.authorDurmaz, Koray
dc.contributor.authorOltulu, Pembe
dc.contributor.authorAtaseven, Arzu
dc.date.accessioned2024-02-23T14:24:05Z
dc.date.available2024-02-23T14:24:05Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractDiscoid lupus erythematosus (DLE) is a chronic inflammatory erythematous skin disease that can be triggered by several factors. Rosacea is another skin disease that causes facial redness and tenderness. Demodex mites have been reported in rosacea and DLE patients commonly in the literature. These two diseases can be seen concomitant, mimic each other clinically and share common possible etiologic factors. To assess demodex mite infestation in both clinical and histopathological findings in DLE patients. We retrospectively evaluated the files of 42 patients with DLE who had been diagnosed DLE based on clinical and histopathological findings between August 2018 and August 2019. Demodex positivity was detected 50% of patients (n = 21). Neutrophile percentages in the dermal and perivascular area were higher in the demodex positive patients (4.43%) than in the Demodex negative patients (2.19%). The intensity of demodex mites correlated positively with dermal neutrophile percentages. ANA was negative in 29 patients (69%) and positive in 13 patients (31%). Anti-dsDNA was negative in serology and follicular plugging was positive in histopathology in all 42 patients (100%). This was a retrospective study. DLE and rosacea share common features in etiopathogenesis and clinical presentation. Inflammation and exacerbations caused by the demodex mites may increase the clinical severity of DLE. Although the position of demodex mites in DLE etiopathogenesis is not known exactly, the presence of high demodex in DLE patients has been determined. Standard skin surface biopsy can be a routine procedure for the evaluation of DLE patients in daily clinical practice.en_US
dc.identifier.doi10.1111/dth.13394
dc.identifier.issn1396-0296
dc.identifier.issn1529-8019
dc.identifier.issue3en_US
dc.identifier.pmid32275797en_US
dc.identifier.scopus2-s2.0-85083851678en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/dth.13394
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13812
dc.identifier.volume33en_US
dc.identifier.wosWOS:000528222000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofDermatologic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFacial Dermatosesen_US
dc.subjectLupus Erythematosusen_US
dc.subjectDiscoiden_US
dc.subjectRosaceaen_US
dc.titleDemodex positive discoid lupus erythematosus: Is it a separate entity or an overlap syndrome?en_US
dc.typeArticleen_US

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