Is Urinary Kidney Injury Molecule-1 a Noninvasive Marker for Renal Scarring in Children With Vesicoureteral Reflux?

Basit Öğe Kaydı
dc.contributor.authorToker, Aysun
dc.contributor.authorZiypak, Tevfik
dc.contributor.authorOrsal, Ebru
dc.contributor.authorLaloglu, Esra
dc.contributor.authorBedir, Fevzi
dc.contributor.authorAksoy, Yilmaz
dc.date.accessioned2024-02-23T14:16:29Z
dc.date.available2024-02-23T14:16:29Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE To examine whether (1) levels of urinary kidney injury molecule-1 (KIM-1), a transmembrane protein and biomarker for renal tubular damage, increase in children with of vesicoureteral reflux (VUR), and (2) if KIM-1 predicts the grade of renal scarring in children with VUR. METHODS The study included 59 VUR patients with renal scarring, 5 VUR patients without renal scarring and 25 healthy controls aged 1 to 17 years. Dimercaptosuccinic acid scans were performed for determination of scarring and graded by 3 independent, blinded pediatric urologists for renal scarring according to the Randomized Intervention for Children with VUR study criteria. Spot urine samples were obtained. Urinary KIM-1 and creatinine levels were measured and the KIM-1/creatinine ratio was calculated. RESULTS Urine geometric mean KIM-1 levels (ng/mg creatinine) were significantly higher in VUR patients than in healthy controls (P = .018). Although the correlation between VUR grade and geometric mean KIM-1 levels was not significant, a positive correlation was found for scarring grade and geometric mean KIM-1 levels (r = .30, P = .02). When the patients were divided by subgroups according to scarring grade (group I, grade 1; group II, grades 2 and 3; group III, grade 4), the log KIM-1 in group III was significantly higher than in group I (P = .004). CONCLUSION Urinary KIM-1 levels might be used as a noninvasive marker, particularly in showing severe scarring in children with VUR. UROLOGY 81: 168-172, 2013. (C) 2013 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.urology.2012.09.004
dc.identifier.endpage172en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue1en_US
dc.identifier.pmid23200959en_US
dc.identifier.scopus2-s2.0-84871977188en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage168en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2012.09.004
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12665
dc.identifier.volume81en_US
dc.identifier.wosWOS:000312960300052en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleIs Urinary Kidney Injury Molecule-1 a Noninvasive Marker for Renal Scarring in Children With Vesicoureteral Reflux?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu