The unguarded-X and the genetic architecture of lifespan: Inbreeding results in a potentially maladaptive sex-specific reduction of female lifespan in Drosophila melanogaster

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dc.contributor.authorSultanova, Zahida
dc.contributor.authorAndic, Muhammed
dc.contributor.authorCarazo, Pau
dc.date.accessioned2024-02-23T14:24:09Z
dc.date.available2024-02-23T14:24:09Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractSex differences in ageing and lifespan are ubiquitous in nature. The unguarded-X hypothesis (UXh) suggests they may be partly due to the expression of recessive mutations in the hemizygous sex chromosomes of the heterogametic sex, which could help explain sex-specific ageing in a broad array of taxa. A prediction central to the UX hypothesis is that inbreeding will decrease the lifespan of the homogametic sex more than the heterogametic sex, because only in the former does inbreeding increase the expression of recessive deleterious mutations. In this study, we test this prediction by examining the effects of inbreeding on the lifespan and fitness of male and female Drosophila melanogaster across different social environments. We found that, across social environments, inbreeding resulted in a greater reduction of female than male lifespan, and that inbreeding effects on fitness did not seem to counterbalance sex-specific effects on lifespan, suggesting the former are maladaptative. Inter- and intra-sexual correlation analyses also allowed us to identify evidence of an underlying joint genetic architecture for inbreeding effects on lifespan. We discuss these results in light of the UXh and other alternative explanations, and suggest that more attention should be paid to the possibility that the unguarded-X may play an important role in the evolution of sex-specific lifespan.en_US
dc.description.sponsorshipSpanish government via a Ramon y Cajal fellowship [RYC-2013-12998]; Spanish government via Excelencia research project [CGL2014-58722-P]en_US
dc.description.sponsorshipWe would like to thank Jeremias Schoreisz for his assistance with the lifespan assays. We also kindly thank the editors and two anonymous reviewers for their comments, which greatly improved the quality of our manuscript. This work was funded by the Spanish government via a Ramon y Cajal fellowship (RYC-2013-12998 to PC) and an Excelencia research project (CGL2014-58722-P to PC).en_US
dc.identifier.doi10.1111/evo.13426
dc.identifier.endpage552en_US
dc.identifier.issn0014-3820
dc.identifier.issn1558-5646
dc.identifier.issue3en_US
dc.identifier.pmid29336481en_US
dc.identifier.scopus2-s2.0-85041352588en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage540en_US
dc.identifier.urihttps://doi.org/10.1111/evo.13426
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13841
dc.identifier.volume72en_US
dc.identifier.wosWOS:000427676800009en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEvolutionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAgeingen_US
dc.subjectAsymmetric Inheritanceen_US
dc.subjectFitnessen_US
dc.subjectSex-Specific Ageingen_US
dc.subjectUnguarded-Xen_US
dc.titleThe unguarded-X and the genetic architecture of lifespan: Inbreeding results in a potentially maladaptive sex-specific reduction of female lifespan in Drosophila melanogasteren_US
dc.typeArticleen_US

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