Effects of artemisinin and hydroxychloroquine on cytokines in experimental sepsis

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dc.contributor.authorBuyukcavlak, M.
dc.contributor.authorDuman, I.
dc.contributor.authorEryavuz, O. D.
dc.contributor.authorUnlu, A.
dc.contributor.authorDuman, A.
dc.date.accessioned2024-02-23T14:40:50Z
dc.date.available2024-02-23T14:40:50Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractPro-and anti-inflammatory cytokines mediate the inflammatory response in sepsis. Therefore, regulation of cytokines with medications in risky situations may protect the patients from sepsis. Hydroxychloroquine and artemisinin are antimalarial drugs with immunomodulatory properties. In this study, we intended to investigate the effects of artemisinin and hydroxychloroquine on the cytokines released during sepsis in the rat model. Twenty-four rats were randomized into four groups. The control group received oral saline, the sepsis group received oral saline and intraperitoneal lipopolysaccharide toxin (LPS), the artemisinin-treated sepsis group received oral 33.33 mg/kg of artemisinin, and the hydroxychloroquine-treated sepsis group received oral 33.33 mg/kg of hydroxychloroquine before LPS injection. Three hours later, serum cytokines were measured. An increase was detected in TNF-a, IL-1, and IL-6 levels in the sepsis group compared to the control (p<0.01). Oral pretreatment with artemisinin resulted in significant downregulation only of IL-1 levels (p<0.01). Cytokines IL-1 and IL-6 were significantly downregulated in the serum of LPS-induced rats pretreated with oral hydroxychloroquine than rats with sepsis (p<0.01). Decreases observed in TNF-a and IL-10 levels were insignificant. These results demonstrated that both artemisinin and hydroxychloroquine attenuate the release of pro-inflammatory cytokines three hours after LPS-induced sepsis in rats. A significant decrease was observed in serum IL-1 and IL-6 levels with hydroxychloroquine and IL-1 levels with artemisinin. Based on our findings, we suggest that the therapeutic potential of artemisinin and hydroxychloroquine may be beneficial in preventing cytokine storm during sepsis, and further research is needed to determine the optimal timing of administration.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Project (BAP) Coordinator [2012/2020]en_US
dc.description.sponsorshipThe authors would like to acknowledge the administration and laboratory technicians in Experimental Medicine Application and Research Center of Selcuk University, for their support. This study was supported by the Selcuk University, Scientific Research Project (BAP) Coordinator, grant number 2012/2020.en_US
dc.identifier.doi10.47665/tb.39.4.010
dc.identifier.endpage551en_US
dc.identifier.issn0127-5720
dc.identifier.issue4en_US
dc.identifier.pmid36602214en_US
dc.identifier.scopus2-s2.0-85145540634en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage547en_US
dc.identifier.urihttps://doi.org/10.47665/tb.39.4.010
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16605
dc.identifier.volume39en_US
dc.identifier.wosWOS:000979411600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMalaysian Soc Parasitology Tropical Medicineen_US
dc.relation.ispartofTropical Biomedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArtemisininen_US
dc.subjectCytokineen_US
dc.subjectHydroxychloroquineen_US
dc.subjectInterleukinen_US
dc.subjectSepsisen_US
dc.titleEffects of artemisinin and hydroxychloroquine on cytokines in experimental sepsisen_US
dc.typeArticleen_US

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