Is major depression associated with serum levels of tumor necrosis factor-alpha in patients with rheumatoid arthritis?

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dc.contributor.authorUguz, Faruk
dc.contributor.authorKucuk, Adem
dc.contributor.authorAydogan, Semra
dc.contributor.authorArslan, Sevket
dc.contributor.authorKurt, Hatice Guncu
dc.contributor.authorToker, Aysun
dc.contributor.authorSahin, Muhammed
dc.date.accessioned2024-02-23T14:13:02Z
dc.date.available2024-02-23T14:13:02Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractObjective: This study presents the serum tumor necrosis factor-alpha (TNF-alpha) levels in rheumatoid arthritis (RA) patients with major depression and without any psychiatric disorder. Methods: The study sample included 61 patients with a diagnosis of RA. Major depression and other psychiatric disorders were screened with the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Blood sample for the determination of serum TNF-alpha level was obtained before the psychiatric interview. Results: The prevalence rates of any depressive disorder and any anxiety disorder were 40.3% (n = 25) and 22.6% (n = 14), respectively. Fifteen (24.2%) patients had major depression alone, whereas 27 (43.5%) patients were not diagnosed with any psychiatric disorder. We could not determine any significant differences between the patients with major depression alone and patients without any psychiatric diagnosis with regard to the serum levels of TNF-alpha. Conclusions: The existence of major depression in RA patients does not seem to be associated with serum levels of TNF-ce. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpsychores.2015.09.011
dc.identifier.endpage532en_US
dc.identifier.issn0022-3999
dc.identifier.issn1879-1360
dc.identifier.issue6en_US
dc.identifier.pmid26493851en_US
dc.identifier.scopus2-s2.0-84951156245en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage530en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychores.2015.09.011
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12270
dc.identifier.volume79en_US
dc.identifier.wosWOS:000366439000010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal Of Psychosomatic Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectDepressionen_US
dc.subjectTumor Necrosis Factor-Alphaen_US
dc.titleIs major depression associated with serum levels of tumor necrosis factor-alpha in patients with rheumatoid arthritis?en_US
dc.typeArticleen_US

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