Dynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with urolithiasis

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dc.contributor.authorSonmez, Mehmet Giray
dc.contributor.authorKozanhan, Betul
dc.contributor.authorDeniz, Cigdem Damla
dc.contributor.authorIyisoy, Mehmet Sinan
dc.contributor.authorKilinc, Muzaffer Tansel
dc.contributor.authorEcer, Gokhan
dc.contributor.authorOzturk, Ahmet
dc.date.accessioned2024-02-23T14:37:57Z
dc.date.available2024-02-23T14:37:57Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractPurpose: A dynamic thiol/disulfide balance is pivotal in organizing anti-oxidant defense, detoxification, apoptosis, and enzyme activities, as well as transcription and cellular signal-transfer mechanisms. The connection between urolithiasis and oxidant/antioxidant status, which can be assessed through thiol-disulfide homeostasis (TDH), has not yet been examined. In this study, we evaluated the effects of TDH on the formation, size, and location of stones by examining the associations between TDH parameters and urolithiasis. Materials and Methods: Patients with urolithiasis and healthy controls were recruited. The patients were divided into subgroups in terms of stone size (>15 mm or <= 15 mm) and stone location (nephrolithiasis or ureterolithiasis). TDH parameters were measured using a novel automatic and spectrophotometric method and compared statistically. Results: TDH parameters were different between the urolithiasis and control groups. TDH tended towards the disulfide side in the urolithiasis group. Stone size increased an average 0.14 mm with a 1 mu mol/L increase in disulfide level and decreased an average 0.058 mm with a 1 mu mol/L increase in native thiol level. Disulfide and native thiol levels were found to be different across patients with stone size >15 mm, <= 15 mm, and controls (p<0.001 and p<0.001, respectively). However, the nephrolithiasis and ureterolithiasis groups were similar in respect of TDH parameters. Conclusions: In this study, it was found that patients with urolithiasis displayed oxidative stress characterized by a TDH tendency towards the disulfide side, and an inadequate antioxidant response identified by a lower level of native thiol as compared with healthy controls.en_US
dc.identifier.doi10.4111/icu.2019.60.4.258
dc.identifier.endpage266en_US
dc.identifier.issn2466-0493
dc.identifier.issn2466-054X
dc.identifier.issue4en_US
dc.identifier.pmid31294135en_US
dc.identifier.scopus2-s2.0-85069195467en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage258en_US
dc.identifier.urihttps://doi.org/10.4111/icu.2019.60.4.258
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16302
dc.identifier.volume60en_US
dc.identifier.wosWOS:000473353400006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Urological Assocen_US
dc.relation.ispartofInvestigative And Clinical Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectDisulfidesen_US
dc.subjectHomeostasisen_US
dc.subjectOxidative Stressen_US
dc.subjectUrolithiasisen_US
dc.titleDynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with urolithiasisen_US
dc.typeArticleen_US

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