Effects of exercise preconditioning on intestinal ischemia-reperfusion injury

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dc.contributor.authorGokbel, H.
dc.contributor.authorOz, M.
dc.contributor.authorOkudan, N.
dc.contributor.authorBelviranli, M.
dc.contributor.authorEsen, H.
dc.date.accessioned2024-02-23T14:37:58Z
dc.date.available2024-02-23T14:37:58Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBackground: To investigate the effects of exercise preconditioning on oxidative injury in the intestinal tissue of rats. Methods: Sixty male Wistar rats were randomly divided into six groups as sham (n = 10), ischemia-reperfusion (n = 10), exercise (n = 10), exercise plus ischemia-reperfusion (n = 10), ischemic preconditioning (n = 10), and ischemic preconditioning plus ischemia-reperfusion groups (n = 10). Tissue levels of malondialdehyde and activities of myeloperoxidase and superoxide dismutase, and serum levels of tumor necrosis factor-alpha and interleukin-6 were measured. Intestinal tissue histopathology was also evaluated by light microscopy. Results: Tumor necrosis factor-alpha concentrations significantly decreased in the exercise group compared to the sham group (p < 0.05). Myeloperoxidase activity significantly increased and superoxide dismutase activity significantly decreased in ischemia-reperfusion group compared to the sham group (p < 0.05). Superoxide dismutase activity in the ischemic preconditioning and ischemic preconditioning plus ischemia-reperfusion groups were significantly higher compared to the ischemia-reperfusion and exercise groups (p < 0.05). Histopathologically, intestinal injury significantly attenuated in the exercise plus ischemia-reperfusion group compared to the ischemia-reperfusion group. Conclusions: The results of the present study indicate that exercise training seems to have a protective role against intestinal ischemia-reperfusion injury (Tab. 3, Fig. 1, Ref. 35). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipResearch Foundation of the Selcuk University, Konya Turkey [09-1102]en_US
dc.description.sponsorshipThis study has been supported by the Research Foundation of the Selcuk University, Konya Turkey (09-1102).en_US
dc.identifier.doi10.4149/BLL_2014_0082
dc.identifier.endpage421en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue7en_US
dc.identifier.pmid25077364en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage416en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_0082
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16310
dc.identifier.volume115en_US
dc.identifier.wosWOS:000340863400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntestinal Ischemia-Reperfusionen_US
dc.subjectExercise Preconditioningen_US
dc.subjectOxidative Statusen_US
dc.titleEffects of exercise preconditioning on intestinal ischemia-reperfusion injuryen_US
dc.typeArticleen_US

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