Memory B cells and serum immunoglobulins are associated with disease severity and mortality in patients with COVID-19

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dc.contributor.authorColkesen, Fatih
dc.contributor.authorKepenek Kurt, Esma
dc.contributor.authorVatansev, Hulya
dc.contributor.authorKorkmaz, Celalettin
dc.contributor.authorColkesen, Fatma
dc.contributor.authorYucel, Fatih
dc.contributor.authorYildiz, Eray
dc.date.accessioned2024-02-23T14:26:13Z
dc.date.available2024-02-23T14:26:13Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractPurpose of the study The aim of this study was to investigate the relationship of B cell-mediated immunity with disease severity and mortality in patients with COVID-19. Study design In this retrospective cohort and single-centre study, 208 patients with laboratory-confirmed COVID-19 were recruited. A COVID-19 severity score, ranging from 0 to 10, was used to evaluate associations between various factors. Serum immunoglobulin levels and the number of cells in B lymphocyte subsets were measured and their association with disease severity and mortality in patients with COVID-19 examined. Results The median age of the patients was 50 (35-63) years and 88 (42%) were female. The number of deceased patients was 17. The median COVID-19 severity score was 8 (6-8) in deceased patients and 1 (0-2) in survivors. Deceased patients had significantly lower levels of total B lymphocytes, naive B cells, switched memory B cells, and serum IgA, IgG, IgG(1) and IgG(2) than recovered patients (all p<0.05). In addition, a significant negative correlation was found between the number of these parameters and COVID-19 severity scores. Decrease in the number of total B cells and switched memory B cells as well as lower serum IgA, IgG and IgG(1) levels were independent risk factors for mortality in patients with COVID-19. Conclusion In the present study, the prognosis of patients with COVID-19 was shown to be associated with the B cell subset and serum immunoglobulin levels.en_US
dc.identifier.doi10.1136/postgradmedj-2021-140540
dc.identifier.endpage771en_US
dc.identifier.issn0032-5473
dc.identifier.issn1469-0756
dc.identifier.issue1164en_US
dc.identifier.scopus2-s2.0-85138489896en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage765en_US
dc.identifier.urihttps://doi.org/10.1136/postgradmedj-2021-140540
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14112
dc.identifier.volume98en_US
dc.identifier.wosWOS:000745053200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofPostgraduate Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCovid-19en_US
dc.subjectImmunologyen_US
dc.subjectGeneral Medicineen_US
dc.subjectRespiratory Infectionsen_US
dc.subjectVirologyen_US
dc.titleMemory B cells and serum immunoglobulins are associated with disease severity and mortality in patients with COVID-19en_US
dc.typeArticleen_US

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