Demographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group

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dc.contributor.authorAydin, Zeki
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorDede, Fatih
dc.contributor.authorYasar, Emre
dc.contributor.authorOzturk, Savas
dc.contributor.authorAydin, Mehmet
dc.contributor.authorTatar, Erhan
dc.date.accessioned2024-02-23T13:55:58Z
dc.date.available2024-02-23T13:55:58Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground In our study, diagnostic and demographic characteristics of patients diagnosed with RPGN by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. According to their types, RPGN patients were classified as type 1 (anti-GBM related), type 2 (immuncomplex related) and type 3 (pauci-immune). Results Of 3875 patients, 200 patients with RPGN (mean age 47.9 +/- 16.7 years) were included in the study which constitutes 5.2% of the total glomerulonephritis database. Renal biopsy was performed in 147 (73.5%) patients due to nephritic syndrome. ANCA positivity was found in 121 (60.5%) patients. Type 1 RPGN was detected in 11 (5.5%), type 2 RPGN in 42 (21%) and type 3 RPGN in 147 (73.5%) patients. Median serum creatinine was 3.4 (1.9-5.7) mg/dl, glomerular filtration rate was 18 (10-37) ml/min/1.73m(2)and proteinuria 2100 (1229-3526) mg/day. The number of crescentic glomeruli ratio was ratio 52.7%. It was observed that urea and creatinine increased and calcium and hemoglobin decreased with increasing crescentic glomerular ratio. Conclusions Our data are generally compatible with the literature. Advanced chronic histopathological findings were prominent in the biopsy of 21 patients. Early biopsy should be performed to confirm the diagnosis of RPGN and to avoid unnecessary intensive immunosuppressive therapy. In addition to the treatments applied, detailed data, including patient and renal survival, are needed.en_US
dc.identifier.doi10.1007/s10157-020-01978-6
dc.identifier.endpage183en_US
dc.identifier.issn1342-1751
dc.identifier.issn1437-7799
dc.identifier.issue2en_US
dc.identifier.pmid33040246en_US
dc.identifier.scopus2-s2.0-85092333096en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.1007/s10157-020-01978-6
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11042
dc.identifier.volume25en_US
dc.identifier.wosWOS:000578672400002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofClinical And Experimental Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRapidly Progressive Glomerulonephritisen_US
dc.subjectAnti-Glomerular Basement Membrane Antibodyen_US
dc.subjectImmune Complex Glomerulonephritisen_US
dc.subjectAnti-Neutrophil Cytoplasmic Antibodyen_US
dc.titleDemographic, clinical and laboratory characteristics of rapidly progressive glomerulonephritis in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Groupen_US
dc.typeArticleen_US

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