Effect of a combined oral contraceptive on patency of arterial anastomosis in a female rat model

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dc.contributor.authorDadaci, Mehmet
dc.contributor.authorOztekin, Can
dc.contributor.authorOztekin, Pelin Seher
dc.contributor.authorSargon, Mustafa Fevzi
dc.contributor.authorOzgur, Figen
dc.date.accessioned2024-02-23T12:53:02Z
dc.date.available2024-02-23T12:53:02Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackgroundOral contraceptives, which may lead to thrombotic events, are widely used drugs by women in reproductive age, some of whom might need emergent or elective microsurgical intervention. This study was planned to investigate the effects of combined oral contraceptives (COC) on arterial anastomosis patency in female rat model. MethodsA third generation COC (ethinyl estradiol and desogestrel) was used in this study. A total of 50 female Wistar albino rats were included. The rats were divided into two groups. Experimental group received 0.03 mg ethinyl estradiol/0.15 mg desogestrel with gastric catheter for 20 days before the surgery. Afterward, the femoral arteries of all rats were divided and anastomosed. The patency of the anastomoses were assessed surgically (at 15 min, 7th day) and radiologically with Doppler ultrasonography (at 3rd and 7th days). The samples were examined using light microscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). ResultsThe early patency assessed in the 15th min showed arterial flow in all rats. But at the 7th day 68% of the anastomosis were patent in the COC group while 100% of the anastomosis were patent in the control group as demonstrated surgically and radiologically (P=0.004). Microscopic examination showed an increase in cytoplasmic organelles and activation of endothelial cells in all rats in the experimental group that received COCs. ConclusionThe present study demonstrated the negative effects of the use of COCs on anastomosis patency in rats. (c) 2015 Wiley Periodicals, Inc. Microsurgery 35:553-559, 2015.en_US
dc.identifier.doi10.1002/micr.22474
dc.identifier.endpage559en_US
dc.identifier.issn0738-1085
dc.identifier.issn1098-2752
dc.identifier.issue7en_US
dc.identifier.pmid26303979en_US
dc.identifier.scopus2-s2.0-84944358014en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage553en_US
dc.identifier.urihttps://doi.org/10.1002/micr.22474
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10607
dc.identifier.volume35en_US
dc.identifier.wosWOS:000363418000009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMicrosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleEffect of a combined oral contraceptive on patency of arterial anastomosis in a female rat modelen_US
dc.typeArticleen_US

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