Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma (PRP) for Treating Androgenic Alopecia

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dc.contributor.authorInce, Bilsev
dc.contributor.authorYildirim, Mehmet Emin Cem
dc.contributor.authorDadaci, Mehmet
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorSavaci, Nedim
dc.date.accessioned2024-02-23T13:43:36Z
dc.date.available2024-02-23T13:43:36Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractAndrogenetic alopecia (AGA), the most common cause of hair loss in both sexes, accounts for 95% of all cases of hair loss. Although the literature has suggested that both nonactivated (n-PRP) and activated autologous (a-PRP) PRP can be used to treat AGA, we did not find any study investigating the use of homologous PRP (h-PRP) for this purpose. Also, to the best of our knowledge, there are no studies comparing the efficacy of h-PRP, a-PRP, or n-PRP on AGA therapy. The aim of this study was to compare the increase in hair density, average number of platelets, complications, preparation, and duration of application in the treatment of AGA using a-PRP, n-PRP, and h-PRP. Between 2014 and 2015, we studied male patients who had experienced increased hair loss in the last year. Patients were divided into three groups: Group 1 received n-PRP, Group 2 received active PRP, and Group 3 received h-PRP. For Group 1, PRP was prepared by a single centrifugation prepared from the patient's own blood. For Group 2, the PRP was prepared from the patient's own blood, but a second centrifugation was applied for platelet activation with calcium chloride. For Group 3, the PRP was prepared from pooled platelets with the same blood group as the patient from the blood center. PRP was injected at 1, 2, and 6 months. The hair density (n/cm(2)) of each patient before and after injection was calculated. Each patient was assigned a fixed evaluation point at the time of application to calculate hair density. At 2, 6, and 12 months after the first treatment, the increase in hair density was calculated as 11.2, 26.1, and 32.4%, respectively, in Group 1; 8.1, 12.5, and 20.8%, respectively, in Group 2; and 16.09, 36.41, and 41.76%, respectively, in Group 3. The increase in hair density was statistically significantly greater in Group 1 than in Group 2 and more so in Group 3 than in both groups among all controls (p < 0.05). The efficacy of both PRPs was determined in AGA treatment in our study. However, it was determined statistically that the increase in hair density with h-PRP was greater than with autologous PRP groups. We believe that h-PRP therapy can be used in patients with AGA presenting with hair loss.en_US
dc.description.sponsorshipNecmettin Erbakan University, Department of Scientific Research projects [161218022]en_US
dc.description.sponsorshipThe authors thank Mehmet Uyar, MD, for his statistical analysis support. This research was supported by Necmettin Erbakan University, Department of Scientific Research projects (No: 161218022).en_US
dc.identifier.doi10.1007/s00266-017-1004-y
dc.identifier.endpage303en_US
dc.identifier.issn0364-216X
dc.identifier.issn1432-5241
dc.identifier.issue1en_US
dc.identifier.pmid29101437en_US
dc.identifier.scopus2-s2.0-85032789613en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://doi.org/10.1007/s00266-017-1004-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10868
dc.identifier.volume42en_US
dc.identifier.wosWOS:000423357400044en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAesthetic Plastic Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrpen_US
dc.subjectAndrogenic Alopeciaen_US
dc.subjectHomologous Platelet-Rich Plasmaen_US
dc.subjectAutologous Platelet-Rich Plasmaen_US
dc.titleComparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma (PRP) for Treating Androgenic Alopeciaen_US
dc.typeArticleen_US

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