Urinary kidney injury molecule-1 levels in renal stone patients

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dc.contributor.authorBalasar, Mehmet
dc.contributor.authorPiskin, Mehmet Mesut
dc.contributor.authorTopcu, Cemile
dc.contributor.authorDemir, Lutfi Saltuk
dc.contributor.authorGurbilek, Mehmet
dc.contributor.authorKandemir, Abdulkadir
dc.contributor.authorOzturk, Ahmet
dc.date.accessioned2024-02-23T13:43:44Z
dc.date.available2024-02-23T13:43:44Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractTo study kidney injury molecule-1 (KIM-1) biomarker levels, indicating renal tubular damage, in patients with kidney stones and in those who underwent minimally invasive method stone treatment. Sixty patients with renal stones between 10 and 20 mm were included into the present study. Patients who were divided into three cohorts underwent micropercutaneous nephrolithotomy (microperc), retrograde intrarenal stone surgery (RIRS), and percutaneous nephrolithotomy (PNL). Urine samples were obtained from all participants before, 4 h and 14 days after the procedure. In all the samples obtained, urinary KIM-1 and creatinine (Cr) levels were measured and KIM-1/Cr ratios (ng/mg creatinine) were calculated. Preoperative urine KIM-1/Cr ratio was higher than postoperative 14th day. The bigger the renal stone size, the higher was the ratio (correlation coefficient 0.353, p = 0.006). According to preferred treatment procedure, there was a statistically significant decrease in preoperative and postoperative 4th hour and 14th day urine KIM-1/Cr rates in the RIRS and PNL, yet none in the microperc group (p = 0.010, p = 0.001, p = 0.212, respectively). In renal stone patients, the elevated urine KIM-1/Cr ratio levels increase further according to stone size. KIM-1/Cr ratio is a promising marker might be helpful in monitoring the damage created by stone disease.en_US
dc.identifier.doi10.1007/s00345-016-1765-y
dc.identifier.endpage1316en_US
dc.identifier.issn0724-4983
dc.identifier.issn1433-8726
dc.identifier.issue9en_US
dc.identifier.pmid26795762en_US
dc.identifier.scopus2-s2.0-84955302953en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1311en_US
dc.identifier.urihttps://doi.org/10.1007/s00345-016-1765-y
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10896
dc.identifier.volume34en_US
dc.identifier.wosWOS:000382175100017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofWorld Journal Of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenal Stoneen_US
dc.subjectKim-1en_US
dc.subjectMicropercen_US
dc.subjectRirsen_US
dc.subjectPnlen_US
dc.titleUrinary kidney injury molecule-1 levels in renal stone patientsen_US
dc.typeArticleen_US

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