Relaxation matters: comparison of in-vitro vasodilatory role of botulinum toxin-A and papaverine in human radial artery grafts

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dc.contributor.authorTanyeli, Omer
dc.contributor.authorDuman, Ipek
dc.contributor.authorDereli, Yuksel
dc.contributor.authorGormus, Niyazi
dc.contributor.authorToy, Hatice
dc.contributor.authorSahin, Ayse Saide
dc.date.accessioned2024-02-23T14:29:07Z
dc.date.available2024-02-23T14:29:07Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description14th National Congress of Turkish-Society-of-Cardiovascular-Surgery -- NOV 03-06, 2016 -- Antalya, TURKEYen_US
dc.description.abstractBackground: Radial artery (RA) is widely used in coronary artery bypass (CABG) surgery and the prevention of spasm is crucial for graft patency. Botulinum toxin A (BTX-A) and B are commonly used for aesthetic reasons and neuromuscular disorders. They are proven to raise blood flow and increase survival of ischemic skin flaps. In this study we evaluated and compared the vasodilator effects of BTX-A and papaverine on human RA grafts. Methods: After resting 60 min in isolated organ baths, human RA grafts were examined. Contraction responses for different doses of serotonin (5-HT) and endothelin-1 (ET-1) were evaluated as a percent of maximum contraction response elicited by 80 mM potassium chloride (KCl). The inhibitory effects of BTX-A and papaverine on contraction responses taken at the 0th hour were compared with the 1st and 2nd hour responses. Inhibitory effects of BTX-A and papaverine against the contractile agent were evaluated by comparing the results of the first and last (0th and 2nd hour) application. Results: In low concentrations, when we compared the effects of BTX-A (10(-8) M) and papaverine (10(-6) M) on 5-HT, papaverine was found to be more effective at both the 0th and 2nd hour (p < 0.05). Both BTX-A and papaverine inhibited the maximum contractile effect of ET-1 to the same extent at the 0th hour; but, the inhibitory effect of BTX-A was significantly stronger at the 2nd hour (p < 0.05). In high concentrations, when we compared the effects of BTX-A (10(-6) M) and papaverine (10(-4) M) on 5-HT, papaverine showed stronger inhibition (p < 0.05), whereas both agents had similar action of inhibition on ET-1 mediated maximum contraction responses. Conclusion: BTX-A inhibits both ET-1 and 5-HT induced contractions and its effectiveness does not decrease over time as observed with papaverine. This study is the first in the literature using human RA for prevention of vasospasm by BTX-A.en_US
dc.description.sponsorshipTurkish Soc Cardiovasc Surgen_US
dc.identifier.doi10.1186/s13019-019-0837-7
dc.identifier.issn1749-8090
dc.identifier.pmid30665449en_US
dc.identifier.scopus2-s2.0-85060254429en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/s13019-019-0837-7
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14549
dc.identifier.volume14en_US
dc.identifier.wosWOS:000456963900002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofJournal Of Cardiothoracic Surgeryen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBotulinum Toxin Aen_US
dc.subjectBotoxen_US
dc.subjectPapaverineen_US
dc.subjectRadial Arteryen_US
dc.subjectVasodilationen_US
dc.subjectCoronary Artery Bypass Graft Surgeryen_US
dc.titleRelaxation matters: comparison of in-vitro vasodilatory role of botulinum toxin-A and papaverine in human radial artery graftsen_US
dc.typeConference Objecten_US

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