Comparison of the Effects of Two Different Analgesics on Bone Regeneration During Mandibular Distraction Osteogenesis

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dc.contributor.authorSabuncuoglu, Fidan Alakus
dc.contributor.authorErsahan, Seyda
dc.contributor.authorAmasyali, Mihri
dc.contributor.authorAvunduk, Mustafa Cihat
dc.date.accessioned2024-02-23T14:23:29Z
dc.date.available2024-02-23T14:23:29Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Mandibular distraction osteogenesis (DO) is frequently used in the management of bone defects and craniofacial deformities, with analgesics commonly administered to relieve acute postoperative pain. This experimental animal study investigated the effects of 2 analgesics, acetaminophen and acemetacin, on bone regeneration after DO. Materials and methods: This study was conducted with 14 mature male New Zealand rabbits (2.8-3.2 kg) randomized into 2 groups of 7. Mandibular osteotomies were performed under optimal operating conditions, and a custom-made distractor was applied to the mandible of each subject, with distraction initiated after a 5-day latency period at a rate of 1.0 mm/d (2 x 0.5 mm/d) for 10 days. Analgesics were administered via oral gavage during the latency period and for the first 5 days of the distraction period for 10 days in total, with group I receiving acetaminophen (200 mg/kg/d) and group II receiving acemetacin (5 mg/kg/d). Subjects were sacrificed and their mandibles dissected at the end of 4 weeks postoperatively. Bone mineral density (BMD) and bone mineral content (BMC) were measured using dual-energy X-ray absorptiometry (DEXA), and histomorphometric analysiswas performed to evaluate the quality of newly formed bone. Paired group comparisons of non-normally distributed numerical variables were made using the Mann-Whitney U test, with a P value of <0.05 considered statistically significant. Results: No significant differences in BMC and BMD values of intact bone, newly formed bone, or bone around the pin site were observed between the 2 groups. Histometric analysis also indicated acetaminophen and acemetacin to have similar effects on bone regeneration during distraction. Conclusion: Acemetacin may be an alternative to acetaminophen for treating pain associated with DO, given the similarities in the effects of the 2 analgesics on bone regeneration. However, this finding should be supported by further experimental and human studies.en_US
dc.identifier.doi10.1097/SCS.0000000000005000
dc.identifier.endpageE85en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue1en_US
dc.identifier.pmid30507875en_US
dc.identifier.scopus2-s2.0-85059918244en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE80en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000005000
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13575
dc.identifier.volume30en_US
dc.identifier.wosWOS:000467712800031en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcemetacinen_US
dc.subjectAcetaminophenen_US
dc.subjectBone Regenerationen_US
dc.subjectDistraction Osteogenesisen_US
dc.titleComparison of the Effects of Two Different Analgesics on Bone Regeneration During Mandibular Distraction Osteogenesisen_US
dc.typeArticleen_US

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