Associations Between Nucleus Size, and Immunohistochemical Galectin-3, Cytokeratine-19 and Hbme-1 Markers in Thyroid Papillary Carcinoma: A Morphometric Analyze

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dc.contributor.authorToy, Hatice
dc.contributor.authorEtli, Ozlem
dc.contributor.authorCelik, Zeliha Esin
dc.contributor.authorAlikanoglu, Arsenal Sezgin
dc.date.accessioned2024-02-23T13:59:56Z
dc.date.available2024-02-23T13:59:56Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractThis study aimed to evaluate the morphometric measurements in cases with papillary thyroid carcinoma, and determine a cut-off value to support diagnosis. Fifty cases with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study with their Galectine-3, CK-19 and HBME-1 immunohistochemical staining results. Demographic and clinical data gathered from pathology reports, which included demographic information such as patients' sex, age, macroscopic tumor size, number of tumor focuses; prognostic parameters such as lenfovascular invasion, perineural invasion, thyroid capsule invasion; and results of immunohistochemical CK- 19, Galectin-3 and HBME-1 staining. Longest nuclear diameters of 150 tumor cells and 150 normal thyrocytes of each case were manually measured in an image analysis software, and mean longest nuclear diameters (MLND-TC and MLND-NC), and also tumor cell/normal cell longest nuclear diameter ratio (TC/NC-LNDR) were calculated. MLND-TC was higher than MLND-NC. The cases with higher MLND-TC had increased risk of capsule invasion in case of a negative staining with Galectine-3, HBME-1, or CK-19. When TC/NC-LNDR was high, number of tumor focus tended to be multiple and lymphovascular invasion risk was also increased. Subtypes of PTC were not differed regarding staining patterns. And finally, increased TC/NC-LNDR was associated with increased risk of having poor prognostic factors. The results of this study suggest that MLND-NC, MLND-TC, and TC/NCLNDR are valuable and easy-to-use measures, which can assist routine histology practice.en_US
dc.identifier.doi10.1007/s12253-017-0337-9
dc.identifier.endpage408en_US
dc.identifier.issn1219-4956
dc.identifier.issn1532-2807
dc.identifier.issue1en_US
dc.identifier.pmid29150742en_US
dc.identifier.scopus2-s2.0-85034216947en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage401en_US
dc.identifier.urihttps://doi.org/10.1007/s12253-017-0337-9
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11370
dc.identifier.volume25en_US
dc.identifier.wosWOS:000456915500045en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPathology & Oncology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPapillary Thyroid Carcinomaen_US
dc.subjectNucleus Diameteren_US
dc.subjectMorphometric Analyzeen_US
dc.titleAssociations Between Nucleus Size, and Immunohistochemical Galectin-3, Cytokeratine-19 and Hbme-1 Markers in Thyroid Papillary Carcinoma: A Morphometric Analyzeen_US
dc.typeArticleen_US

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