Impact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinoma

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dc.contributor.authorTuran, Nedim
dc.contributor.authorBenekli, Mustafa
dc.contributor.authorUnal, Olcun Umit
dc.contributor.authorUnek, Ilkay Tugba
dc.contributor.authorTastekin, Didem
dc.contributor.authorDane, Faysal
dc.contributor.authorAlgin, Efnan
dc.date.accessioned2024-02-23T14:37:32Z
dc.date.available2024-02-23T14:37:32Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma (PAC). Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013. Results: Of 563 patients, 472 received adjuvant chemotherapy (CT) alone, chemoradiotherapy (CRT) alone, and chemoradiotherapy plus chemotherapy (CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival (RFS) and overall survival (OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant difference between groups when patients with node-negative disease or patients with or without positive surgical margins were considered. Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.en_US
dc.identifier.doi10.3978/j.issn.1000-9604.2015.08.03
dc.identifier.endpage416en_US
dc.identifier.issn1000-9604
dc.identifier.issn1993-0631
dc.identifier.issue4en_US
dc.identifier.pmid26361410en_US
dc.identifier.scopus2-s2.0-84940553386en_US
dc.identifier.startpage408en_US
dc.identifier.urihttps://doi.org/10.3978/j.issn.1000-9604.2015.08.03
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16148
dc.identifier.volume27en_US
dc.identifier.wosWOS:000360940900010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAme Publ Coen_US
dc.relation.ispartofChinese Journal Of Cancer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPancreatic Adenocarcinomaen_US
dc.subjectAdjuvant Chemotherapy (Adjuvant Ct)en_US
dc.subjectAdjuvant Radiotherapyen_US
dc.titleImpact of adjuvant treatment modalities on survival outcomes in curatively resected pancreatic and periampullary adenocarcinomaen_US
dc.typeArticleen_US

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