Transorbital Ultrasonographic Measurement of Optic Nerve Sheath Diameter in Brain Death

Basit Öğe Kaydı
dc.contributor.authorTopcuoglu, Mehmet A.
dc.contributor.authorArsava, E. Murat
dc.contributor.authorBas, D. Funda
dc.contributor.authorKozak, Hasan H.
dc.date.accessioned2024-02-23T14:24:31Z
dc.date.available2024-02-23T14:24:31Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBACKGROUNDUltrasonographic measurement of optic nerve sheath diameter (ONSD) can successfully be used to estimate intracranial pressure (ICP) elevation. Its utility in corroboration of brain death (BD) was herein studied. METHODSONSD was measured in 29 subjects with BD; in 19 comatose patients (with raised ICP in 11), 20 patients with various neurological diseases, and 40 healthy control subjects. The distance between the inner and outer edges of the echolucent lines around hyperechoic area surrounding the optic nerve (ON) was identified as ONSD external (ONSDe) and ONSD internal (ONSDi). RESULTSCompared to patients with neurological diseases (5.75 .79 mm) or healthy controls (5.98 +/- .63 mm), ONSDe was significantly higher in comatose patients (7.61 +/- .97 and 6.71 +/- 1.07 mm in those with and without raised ICP) and BD subjects (8.34 +/- .66 mm). ONSDi showed similar trends across the groups: 6.09 +/- .71 mm in BD; 5.89 +/- .37 mm in comatose control with elevated ICP; 5.16 +/- .49 mm in comatose control with normal ICP; 4.36 +/- .68 mm in neurological control; 4.69 +/- .67 mm in healthy control. The accuracy of ONSDe measurements in differentiating patients with ICP elevation (n = 40) was .965 as determined by area under the curve (AUC) of receiver-operator characteristics curves. Similarly, accuracy in discrimination of BD was .952. However, ONSDe showed limited yield to identify BD cases among comatose patients with Glasgow coma scale score of 3, where accuracy was .803 (95% CI: .709-.816) and decreased further to .722 (95% CI: .610-.816) when analyses were restricted to comatose patients with ICP elevation. AUC values for ONSDi was similar or lower. CONCLUSIONONSD is significantly greater in subjects with BD. However, quantification of ONSD cannot discriminate BD subjects from comatose ones with raised ICP with 100% certainty.en_US
dc.identifier.doi10.1111/jon.12233
dc.identifier.endpage909en_US
dc.identifier.issn1051-2284
dc.identifier.issn1552-6569
dc.identifier.issue6en_US
dc.identifier.pmid25800801en_US
dc.identifier.scopus2-s2.0-84944515518en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage906en_US
dc.identifier.urihttps://doi.org/10.1111/jon.12233
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13984
dc.identifier.volume25en_US
dc.identifier.wosWOS:000363334100008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Neuroimagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiagnosisen_US
dc.subjectSpecificityen_US
dc.subjectOptic Nerve Sheath Diameteren_US
dc.subjectRaised Intracranial Pressureen_US
dc.subjectBrain Deathen_US
dc.titleTransorbital Ultrasonographic Measurement of Optic Nerve Sheath Diameter in Brain Deathen_US
dc.typeArticleen_US

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