Investigation of the effects of antidepressant treatment on hippocampus and hypothalamus endoplasmic reticulum stress in chronic mild stress induced depression in rats

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dc.contributor.authorKaraagac, Mustafa
dc.contributor.authorAk, Mehmet
dc.contributor.authorKurar, Ercan
dc.contributor.authorUguz, Faruk
dc.contributor.authorKutlu, Selim
dc.date.accessioned2024-02-23T14:41:36Z
dc.date.available2024-02-23T14:41:36Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjective: This study aimed to examine the role of endoplasmic reticulum (ER) stress in the pathophysiology of depression in female rats exposed to the chronic mild stress model.Method: Chronic mild stress model was constituted in 48 female adult rats were and divided into 4 groups as control, depression, depression+1 mg/kg sertraline, and depression+10 mg/kg sertraline. Subcutaneous drug infusions were performed for 14 days using osmotic minipumps. Expression levels of genes in ER stress pathway were evalulated in hypothalamus and hippocampus tissues of rats. Results: It was found that ATF4 gene expression increased in depression in the hippocampus and decreased with treatment. Hippocampal GRP78 gene expression was downregulated after treatment. Hypothalamic and hippocampal CALR gene expression decreased with treatment, hypothalamic HSP47 gene expression decreased in both treatment groups. Hypothalamic and hippocampal XPB1 gene expression decreased with treatment, hippocampal XPB1 gene expression was further downregulated in the depression +10 mg/kg sertraline group compared to the depression+1 mg/kg sertraline group.Discussion: These findings show that the ER stress mechanism may have a role in the pathophysiology of depression and that this mechanism can be reversed with treatment. The results of our study have been encouraging for human studies and open the way for new projects to understand and accelerate the antidepressant effect.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordination Unit [201518013]en_US
dc.description.sponsorshipThis study was supported by Necmettin Erbakan University Scientific Research Projects Coordination Unit (project number: 201518013) . This study was also presented in Psychopharmacology 2021 Congress.en_US
dc.identifier.doi10.5505/kpd.2023.43410
dc.identifier.endpage247en_US
dc.identifier.issn1302-0099
dc.identifier.issn2146-7153
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85180323344en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org/10.5505/kpd.2023.43410
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16924
dc.identifier.volume26en_US
dc.identifier.wosWOS:001127318700004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKlinik Psikiyatri Dergisien_US
dc.relation.ispartofKlinik Psikiyatri Dergisi-Turkish Journal Of Clinical Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMajor Depressionen_US
dc.subjectEndoplasmic Reticulumen_US
dc.subjectChronic Mild Stress Modelen_US
dc.subjectSertralineen_US
dc.subjectGene Expressionen_US
dc.titleInvestigation of the effects of antidepressant treatment on hippocampus and hypothalamus endoplasmic reticulum stress in chronic mild stress induced depression in ratsen_US
dc.typeArticleen_US

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