The Efficiency of Hepatitis C Virus Core Antigen Test in the Diagnosis of Hepatitis C Infection

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dc.contributor.authorDemircili, Mehmet Emin
dc.contributor.authorOzdemir, Mehmet
dc.contributor.authorFeyzioglu, Bahadir
dc.contributor.authorBaysal, Bulent
dc.date.accessioned2024-02-23T14:38:23Z
dc.date.available2024-02-23T14:38:23Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractObjective: It was aimed to investigate diagnostic value of hepatitis C virus (HCV) core antigen test in patients with positive or negative anti-HCV assay by comparing with HCV ribonucleic acid (RNA) assay. Materials and Methods: Serum samples obtained from 189 patients who were admitted to Necmettin Erbakan University Meram Faculty of Medicine between December 2010 and February 2012, and HCV RNA assay were carried out for various reasons. Two mL of samples were stored under suitable conditions and anti-HCV, HCV core antigen and strip immunoblot assay [Commercial INNO LIA (TM) HCV Score (Innogenetics NV in Ghent, Belgium)] were performed. Genotyping was performed in the amplicons of the samples with positive HCV RNA test. Results: The diagnostic sensitivity specificity, negative predictive value and positive predictive value of HCV core antigen test were 96.2%, 100%, 97.3%, and 100%, respectively. Sixty-five serum samples were genotyped and their distribution were detected: Fifty-nine samples were genotype 1b, 2-genotype 1a/1b, 1-genotype 3a, 1-genotype 4, 1-genotype 2a/2c, and 1 was genotype 1a. Conclusion: It was concluded that HCV core antigen assay is highly specific, sensitive, reliable, reproducible, and easy to perform. It may be applied as a supplemental and confirmatory test in anti-HCV assays in the diagnosis of HCV.en_US
dc.description.sponsorshipScientific Research Projectsen_US
dc.description.sponsorshipThis study was supported by Scientific Research Projects.en_US
dc.identifier.doi10.4274/vhd.78300
dc.identifier.endpage22en_US
dc.identifier.issn1307-9441
dc.identifier.issn2147-2939
dc.identifier.issue1en_US
dc.identifier.startpage18en_US
dc.identifier.urihttps://doi.org/10.4274/vhd.78300
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16499
dc.identifier.volume22en_US
dc.identifier.wosWOS:000381726500005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofViral Hepatit Dergisi-Viral Hepatitis Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatitis C Virusen_US
dc.subjectCore Antigenen_US
dc.subjectHepatitis C Virus Ribonucleic Aciden_US
dc.subjectStrip Immunoblot Assayen_US
dc.titleThe Efficiency of Hepatitis C Virus Core Antigen Test in the Diagnosis of Hepatitis C Infectionen_US
dc.typeArticleen_US

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