Effectiveness of gonarthrosis treatment via intra-articular injections of linear vs. cross-linked hyaluronic acids

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dc.contributor.authorYilmaz, Selcuk
dc.contributor.authorKurt, Mehmet
dc.contributor.authorKekec, Ahmet Fevzi
dc.contributor.authorYildirim, Ahmet
dc.date.accessioned2024-02-23T14:41:24Z
dc.date.available2024-02-23T14:41:24Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjectives: The study aimed to compare the outcomes of single-dose cross-linked hyaluronic acid and the linear regimen of three doses of HA knee injections among patients with gonarthrosis.Patients and methods: This single-center, retrospective study was conducted with 60 patients (47 females, 13 males; mean age: 57.9 +/- 4.29 years; range, 50 to 65 years) with Kellgren-Lawrence Grade 2 or 3 gonarthrosis between February 2020 and February 2022. Patients were either subjected to intra-articular cross-linked hyaluronic acid (n=30) or linear hyaluronic acid (n=30) injection treatments. Comprehensive assessments of the patients were conducted prior to the injections, as well as at three and six months after injection. The two injection groups were compared regarding the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Oxford Knee Score.Results: Both injections showed a statistically significant improvement from baseline in both WOMAC and Oxford Knee Score at three and six months (p<0.001). There was no notable distinction in the alteration of WOMAC knee scores between the two injection types. However, a notable discrepancy was observed in the elevation of Oxford Knee Score among patients who received cross-linked knee injections compared to those who underwent linear hyaluronic acid knee injections, signifying a significant increase in the former group (p<0.001).Conclusion: The advantage of a single-dose administration of cross-linked HA knee injections, as opposed to the three-dose regimen required for linear hyaluronic acid, translates into reduced time and cost for the injection process. Moreover, this approach minimizes injection-associated discomfort for patients due to the singular dose administration.en_US
dc.identifier.doi10.52312/jdrs.2023.1403
dc.identifier.issn2687-4792
dc.identifier.pmid38108175en_US
dc.identifier.scopus2-s2.0-85180383933en_US
dc.identifier.urihttps://doi.org/10.52312/jdrs.2023.1403
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16840
dc.identifier.wosWOS:001110701800001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Joint Diseases Foundationen_US
dc.relation.ispartofJoint Diseases And Related Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectConservative Treatmenten_US
dc.subjectGonarthrosisen_US
dc.subjectHyaluronic Aciden_US
dc.subjectVisco-Supplementationen_US
dc.titleEffectiveness of gonarthrosis treatment via intra-articular injections of linear vs. cross-linked hyaluronic acidsen_US
dc.typeArticleen_US

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