A Unique Gut Microbiome-Physical Function Axis Exists in Older People with HIV: An Exploratory Study

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dc.contributor.authorDillon, Stephanie M.
dc.contributor.authorAbdo, Mona H.
dc.contributor.authorWilson, Melissa P.
dc.contributor.authorLiu, Jay
dc.contributor.authorJankowski, Catherine M.
dc.contributor.authorRobertson, Charles E.
dc.contributor.authorTuncil, Yunus
dc.date.accessioned2024-02-23T14:20:51Z
dc.date.available2024-02-23T14:20:51Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractImpairments in physical function and increased systemic levels of inflammation have been observed in middle-aged and older persons with HIV (PWH). We previously demonstrated that in older persons, associations between gut microbiota and inflammation differed by HIV serostatus. To determine whether relationships between the gut microbiome and physical function measurements would also be distinct between older persons with and without HIV, we reanalyzed existing gut microbiome and short chain fatty acid (SCFA) data in conjunction with previously collected measurements of physical function and body composition from the same cohorts of older (51-74 years), nonfrail PWH receiving effective antiretroviral therapy (N = 14) and age-balanced uninfected controls (N = 22). Associations between relative abundance (RA) of the most abundant bacterial taxa or stool SCFA levels with physical function and body composition were tested using HIV-adjusted linear regression models. In older PWH, but not in controls, greater RA of Alistipes, Escherichia, Prevotella, Megasphaera, and Subdoligranulum were associated with reduced lower extremity muscle function, decreased lean mass, or lower Short Physical Performance Battery (SPPB) scores. Conversely, greater RA of Dorea, Coprococcus, and Phascolarctobacterium in older PWH were associated with better muscle function, lean mass, and SPPB scores. Higher levels of the SCFA butyrate associated with increased grip strength in both PWH and controls. Our findings indicate that in older PWH, both negative and positive associations exist between stool microbiota abundance and physical function. Different relationships were observed in older uninfected persons, suggesting features of a unique gut-physical function axis in PWH.en_US
dc.description.sponsorshipNational Institute of Aging of the National Institutes of Health [K23AG050260, T32 AG279-15]; Gilead Sciences Research Scholars Program in HIV; NCATS Colorado CTSA [UL1TR002535]; GI and Liver Innate Immune Program (GALIIP) of the University of Colorado Anschutz Medical Campusen_US
dc.description.sponsorshipThis work was supported by the National Institute of Aging of the National Institutes of Health [K23AG050260] to Kristine M. Erlandson, T32 AG279-15 to Jay Liu, the Gilead Sciences Research Scholars Program in HIV (to Kristine M. Erlandson), and the NCATS Colorado CTSA grant number UL1TR002535 to Kristine M. Erlandson. Cara C. Wilson, Daniel N. Frank, and Charles E. Robertson were supported in part by the GI and Liver Innate Immune Program (GALIIP) of the University of Colorado Anschutz Medical Campus.en_US
dc.identifier.doi10.1089/aid.2020.0283
dc.identifier.endpage550en_US
dc.identifier.issn0889-2229
dc.identifier.issn1931-8405
dc.identifier.issue7en_US
dc.identifier.pmid33787299en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage542en_US
dc.identifier.urihttps://doi.org/10.1089/aid.2020.0283
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13344
dc.identifier.volume37en_US
dc.identifier.wosWOS:000646785500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofAids Research And Human Retrovirusesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHiven_US
dc.subjectAgingen_US
dc.subjectPhysical Functionen_US
dc.subjectMicrobiomeen_US
dc.subjectInflammationen_US
dc.titleA Unique Gut Microbiome-Physical Function Axis Exists in Older People with HIV: An Exploratory Studyen_US
dc.typeArticleen_US

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